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MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15525 | MetaboLights
MetabolomicsMechanisms of Etomidate Addiction and Neuro-Hepatic Toxicity: Molecular Pathway Analysis Based on Multi-Omics Integration
Etomidate has been linked to addictive behaviors and neurotoxic and hepatotoxic effects. We established a mouse exposure model across graded etomidate doses and assessed reward using conditioned place preference (CPP). Proteomic and metabolomic profiling of cerebral tissue and right hepatic lobe tis...
2026-09-02 | MTBLS15524 | MetaboLights
TranscriptomicsAnalysis of transcripts in PNA-A(15) oligo treated human HEK-293 cells
Mononucleotide A and T repeats are abundant in human genome. Many of A repeats are bound by Argonaute proteins (AGOs). To evaluate the role of AGOs and A repeats in gene regulation, HEK293 cells were treated with 8-amino-3,6-dioxaoctanoic acid added peptide nucleic acid (PNA) AAAAAAAAAAAAAAA oligo (...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-43185 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2
HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral b...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4883 | biostudies-arrayexpress
TranscriptomicsEffect of LIF and IL-6 on gene expression in JEG-3 and HTR-8/SVneo trophoblastic cells
Both leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) increase the invasiveness of JEG-3 and HTR-8/SVneo cells. This study examines the effect of LIF and IL-6 on gene expression in trophoblastic cell models viz. JEG-3 and HTR-8/SVneo cells to decipher the molecular basis of the increase in ...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-36202 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell line CGR8 treated with Leukemia Inhibitory Factor (LIF) to identify LIF-dependent genes and early differentiation markers
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at the University Bordeaux 2 (CNRS UMR 5164). The purpose of the exper...
ORGANISM(S): Mus musculus 
2009-07-10 | E-TABM-667 | biostudies-arrayexpress
ProteomicsProtein Contaminants Matter: Building Universal Protein Contaminant Libraries for DDA and DIA Proteomics
Mass spectrometry-based proteomics is challenged by the presence of contaminant background signals. In particular, protein contaminants from reagents and sample handling are often abundant and almost impossible to avoid, reducing the sensitivity, specificity and reproducibility of protein identifica...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-01-21 | MSV000088714 | MassIVE
UnknownInsecurity, polio vaccination rates, and polio incidence in northwest Pakistan.
Not available
S-EPMC5816148 | biostudies-literature
Proteomics,MultiomicsDIA-Umpire: comprehensive computational framework for data independent acquisition proteomics
This dataset consists of 44 raw MS files, comprising 27 DIA (SWATH) and 15 DDA runs on a TripleTOF 5600 and of two raw mass spectrometry files acquired on a Q Exactive. The composition of the dataset is described in the manuscript by Tsou et al., titled: "DIA-Umpire: comprehensive computational fra...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) Homo Sapiens (ncbitaxon:9606) 
2017-04-27 | MSV000081023 | MassIVE
UnknownUse it too much and lose everything? The effects of hours of work on health.
Not available
S-EPMC9647391 | biostudies-literature
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