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TranscriptomicsTranscription profiling of mouse CD4+ T cells gene-transduced with AML1, wild type Foxp3, and a Foxp3 mutant defective in binding to AML1
To clarify how Foxp3 regulates its target genes, we performed co-immunoprecipitation experiments and found that Foxp3 physically bound to AML1/Runx1 (Ono, M. et al, Nature, 2007). In this series of study, we compared gene regulations by AML1, wild type Foxp3, and a Foxp3 mutant with defective bindin...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6939 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of FoxP3-expressing or non-expressing subsets of human CD4+ T cells
Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. Abstract: FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15659 | biostudies-arrayexpress
TranscriptomicsDifferential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation
Dorsomorphin is a small molecule inhibitor of type I bone morphogenic protein receptors (BMPRs). We have found that dorsomorphin affects a wide range of T cell function. In order to obtain the bigger picture of the effects of DM in T cell activation. transcriptomic analysis was performed using mouse...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-27378 | biostudies-arrayexpress
UnknownFirst-in-human study of ONO-4578, an antagonist of prostaglandin E2 receptor 4, alone and with nivolumab in solid tumors.
Not available
S-EPMC9807514 | biostudies-literature
UnknownRandomised clinical trial: exploratory phase 2 study of ONO-2952 in diarrhoea-predominant irritable bowel syndrome.
Not available
S-EPMC5157770 | biostudies-literature
UnknownONO-4578 Plus Nivolumab in Unresectable Advanced or Recurrent Gastric or Gastroesophageal Junction Cancer.
Not available
S-EPMC12400061 | biostudies-literature
TranscriptomicsHedgehog signaling in T cell differentiation
Despite Hedgehog’s influence on T-cell activation and proliferation, the transcriptional targets of Gli2 in lymphocytes are not known. We therefore examined the Hedgehog-dependent transcriptional response of resting and early-stage activated T-cells in order to define their transcriptional response...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-33156 | biostudies-arrayexpress
UnknownEvaluation of the effectiveness and safety of ONO-2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo-controlled, double-blind study in Japanese patients.
Not available
S-EPMC12862990 | biostudies-literature
UnknownOptimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391).
Not available
S-EPMC12621189 | biostudies-literature
UnknownThree-year follow-up results from phase II studies of nivolumab in Japanese patients with previously treated advanced non-small cell lung cancer: Pooled analysis of ONO-4538-05 and ONO-4538-06 studies.
Not available
S-EPMC6718542 | biostudies-literature
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