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TranscriptomicsGenome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3
Differentiation of naive CD4 T cells into type 2 helper (Th2) cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes including those encoding Th2 cytokines. IL-4-mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-28292 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity
Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear. GATA3, a master regulator of Th2 cell differentiation...
ORGANISM(S): Mus musculus 
2013-04-19 | E-GEOD-46185 | biostudies-arrayexpress
TranscriptomicsSpatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes
Trithorax group (TrxG) and Polycomb group (PcG) proteins are two mutually antagonistic chromatin modifying complexes, however, how they together mediate transcriptional counterregulation remains unknown. Genome-wide analysis revealed that binding of Ezh2 and Menin, central members of the PcG and Tr...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-72757 | biostudies-arrayexpress
GenomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells [ChIP-seq]
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-24 | E-GEOD-51079 | biostudies-arrayexpress
TranscriptomicsThe polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.
Following antigen encounter by CD4 T cells, polarizing cytokines induce the expression of master regulators that control differentiation. Inactivation of the histone methyltransferase Ezh2 was found to specifically enhance T-helper (Th)1 and Th2 cell differentiation and plasticity. Ezh2 directly bo...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-50729 | biostudies-arrayexpress
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-16 | PXD023477 | JPOST Repository
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