Proteomics

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Proteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice

ABSTRACT: CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO mice accumulate matrisome proteins in cerebral blood vessels. We isolated pial arteries (the anterior cerebral artery and the middle cerebral artery) from candesartan-treated and nontreated Htra1-KO mice at 24 months of age.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Taisuke Kato 

PROVIDER: PXD023477 | JPOST Repository | Tue Nov 16 00:00:00 GMT 2021

REPOSITORIES: jPOST

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Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model.

Kato Taisuke T   Manabe Ri-Ichiroh RI   Igarashi Hironaka H   Kametani Fuyuki F   Hirokawa Sachiko S   Sekine Yumi Y   Fujita Natsumi N   Saito Satoshi S   Kawashima Yusuke Y   Hatano Yuya Y   Ando Shoichiro S   Nozaki Hiroaki H   Sugai Akihiro A   Uemura Masahiro M   Fukunaga Masaki M   Sato Toshiya T   Koyama Akihide A   Saito Rie R   Sugie Atsushi A   Toyoshima Yasuko Y   Kawata Hirotoshi H   Murayama Shigeo S   Matsumoto Masaki M   Kakita Akiyoshi A   Hasegawa Masato M   Ihara Masafumi M   Kanazawa Masato M   Nishizawa Masatoyo M   Tsuji Shoji S   Onodera Osamu O  

The Journal of clinical investigation 20211101 22

Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high-temperature requirement A1 (HTRA1) serine protease activity. In CARASIL, arteriopathy causes intimal thickening, smooth muscle cell (SMC) degeneration, elastic lamina splitting, and vasodilation. The molecular mechanisms were proposed to involve the a  ...[more]

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