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MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
MetabolomicsComprehensive multi-omics analysis reveals the influence of epigenetic mechanisms on porcine oocyte maturation
In vitro maturation (IVM) oocyte is a key component of assisted reproduction in pigs. Asynchronous nucleoplasmic maturation and incomplete cytoplasmic maturation is one of the key factors for impaired maturation and quality of oocytes matured in vitro. Although Single-omics techniques have been appl...
2025-08-27 | MTBLS12325 | MetaboLights
MetabolomicsResolvin E1 in follicular fluid acts as a potential biomarker and improves oocyte developmental competence by optimizing cumulus cells

The metabolic profile of follicular fluid (FF) has been investigated to look for biomarkers for oocyte quality. Resolvin E1 (RvE1), a potent pro-resolving mediator, was reported to have protective action in cell function. The study aimed to examine the predictive value of RvE1 for oocyte quality ...

2020-03-26 | MTBLS1488 | MetaboLights
TranscriptomicsComparison of the human oocyte to its sister polar body
Clinicians need additional metrics for predicting quality of human oocytes for IVF procedures. Human polar bodies reflect the oocyte transcript profile. Quantitation of polar body mRNAs could allow for both oocyte ranking and embryo preferences in IVF applications. The transcriptome of a polar body ...
ORGANISM(S): Homo sapiens 
2011-10-12 | E-GEOD-32689 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the oocyte quality
Microarray analysis was performed in ooplast samples to identify gene expression profiles associated with the embryo capacity to develop to blastocyst stage A fraction of the cytoplasm from in vitro matured oocytes was collected and snap frozen. The oocytes were chemically activated and presumptive ...
ORGANISM(S): Bos taurus 
2013-12-27 | E-GEOD-29191 | biostudies-arrayexpress
MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
GenomicsNEDDylation modifies mitochondrial transcription to maintain oocyte quality (Oocyte)
NEDDylation modifies mitochondrial transcription to maintain oocyte quality (Oocyte)
PRJNA1143033 | ENA
ProteomicsGrowth hormone supplementation reduces aneuploidy and improves the quality of oocytes by activating ERK1/2 pathway in aged mice
The decline in oocyte quality is a limiting factor of female fertility; however, strategies to maintain the oocyte quality of aged women are not available. In this study, we showed that growth hormone (GH) supplementation in vivo not only alleviated the decline in oocyte number caused by aging, but ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039147 | Pride
Aneuploidy Oocyte quality Aged oocytes Growth hormone 
TranscriptomicsDifferentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]
Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) ans embryo of poor quality (E).
ORGANISM(S): Homo sapiens 
2012-12-10 | E-GEOD-37117 | biostudies-arrayexpress
Proteomicsquantitative proteomic analysis of mouse oocyte of different chromatin configurations
Chromatin configuration serves as a principal indicator of GV (germinal vesicle)-stage oocyte quality. In this study, a quantitative proteomics method was applied to investigate the the underlying mechanisms governing the chromatin configuration.
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD048173 | Pride
Chromatin configuration Mouse Tmt Oocyte 
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