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MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
ProteomicsConsequences of aneuploidy in human fibroblasts
To characterize aneuploidy driven phenotypes in human trisomies, we performed global transcriptome, proteome, and phenotypic analysis of primary human fibroblasts from individuals with Patau (trisomy 13), Edwards (trisomy 18), or Down syndromes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-09 | MSV000085706 | MassIVE
TranscriptomicsUniform response to aneuploidy in human cells
There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far. To uncover a uniform transcriptional response to aneuploidy we evaluted the transcription profiles of trisomic and tetrasomic cell li...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-47830 | biostudies-arrayexpress
TranscriptomicsAneuploidy-induced cellular stresses limit autophagic degradation.
An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Determining how aneuploidy affects cells is thus critical to understanding tumorigenesis. Here we show that aneuploidy interferes with the degradation of autophagosomes...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-60570 | biostudies-arrayexpress
TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts
Preimplantation genetic diagnosis (PGD) of aneuploidy by fluorescence in situ hybridisation (FISH) has not delivered the expected clinical benefit. Many previous re-analysis studies of embryos deemed aneuploid by FISH on day 3 have found a high degree of chromosomal normalcy at the blastocyst stage...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-18932 | biostudies-arrayexpress
GenomicsMosaic Chromosomal Aneuploidy
Mosaic Chromosomal Aneuploidy
PRJNA437526 | ENA
GenomicsMosaic Chromosomal Aneuploidy
Mosaic Chromosomal Aneuploidy
PRJNA437525 | ENA
GenomicsAneuploidy
Aneuploidy promotes genomic instability by impairing DNA replication
PRJEB7596 | ENA
ProteomicsQuantitative Proteomic Analysis Reveals Posttranslational Responses to Aneuploidy in Yeast
Aneuploidy causes severe developmental defects and is a near universal feature of tumor cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well characterized. Here, we examined the consequences of aneuploidy on the proteome of aneuploid budding yeast strains. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-08-14 | PXD001019 | Pride
Tmt Silac Aneuploidy Saccharomyces cerevisiae 
TranscriptomicsSNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH
Many studies estimate that chromosomal mosaicism within the cleavage stage human embryo is high. However, comparison of two unique methods of aneuploidy screening of blastomeres within the same embryo has not been conducted and may indicate whether mosaicism is overestimated due to technical incons...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-20975 | biostudies-arrayexpress
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