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ProteomicsHA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
G protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a novel mouse model by fusing the hemagglutinin (HA)-epitope tag sequence to the amino-terminus of the µ-opioid receptor (MOP). Although HA-MOP knock-in ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD027825 | Pride
Brain Mouse Pharmacology Mop splice variants Opioid receptor family Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsAgonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists for the nociceptin/orphanin FQ opioid peptide NOP receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those for other members of the opioid receptor family. Therefore, we investig...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012908 | Pride
Brain Opioid receptor family Mouse Biological Pharmacology Post-translational modification Nanolc-ms/ms cid/etd Phosphorylation 
TranscriptomicsOpioid exacerbates gut dysbiosis in a murine model Citrobacter rodentium infection
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
2020-02-18 | E-MTAB-7503 | biostudies-arrayexpress
UnknownLabel-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
Not available
S-EPMC3602246 | biostudies-literature
Unknownμ Opioid receptor: novel antagonists and structural modeling.
Not available
S-EPMC4757823 | biostudies-literature
UnknownDecoding Partner Specificity of Opioid Receptor Family.
Not available
S-EPMC8490921 | biostudies-literature
ProteomicsA specific Kinase-substrate Regulation Network upon κ-opioid Receptor Activation
Kappa Opioid receptors（KORs） belong to family A of G-protein–coupled receptors (GPCRs), and the involvement of their ligands in analgesia and sedation has been extensively studied. KORs, which are expressed in the central and peripheral nervous systems are well known to exert potent anti-nociceptive...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD008349 | Pride
Phosphoproteome Dimethyl labeling Κ-opioid receptor 
UnknownDynamics of agonist-evoked opioid receptor activation revealed by FRET- and BRET-based opioid receptor conformation sensors.
Not available
S-EPMC11806106 | biostudies-literature
UnknownTargeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?
Not available
S-EPMC7373229 | biostudies-literature
GenomicsA Genome-Wide Association Study of Heroin Dependence

This collaboration of Australian and American investigators aims to identify genes associated with liability for heroin dependence. The project uses a case-control design in which cases met lifetime DSM-IV criteria for heroin dependence. Controls included assessed individuals who did not meet DSM...

phs000277.v1.p1 | EGA
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