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TranscriptomicsPluripotent embryonic stem cells and multipotent adult germline stem cells reveal similar transcriptomes including pluripotency-related genes
DNA microarray analysis was performed with mouse multipotent adult germline stem cells (maGSCs) and embryonic stem cells (ESCs) from different genetic backgrounds cultured under standard ESC culture conditions and under differentiation-promoting conditions by the withdrawal of Leukemia Inhibitory Fa...
ORGANISM(S): Mus musculus 
2010-07-12 | E-GEOD-22605 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human slow flow venous malformations and normal saphenous veins
Objective: Vascular malformations affect 3% of neonates. Venous malformations (VMs) are the largest group representing more than 50 % of cases. In hereditary forms of VMs gene mutations have been identified, but for the large group of spontaneous forms the primary cause and downstream dysregulated g...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human oligodendrocytes identifies o Tmem10/Opalin as a novel marker
Background; During the development of the central nervous system, oligodendrocytes generate large amounts of myelin, a multilayered insulating membrane that ensheathes axons, thereby allowing the fast conduction of the action potential and maintaining axonal integrity. Differentiation of oligodendro...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-10291 | biostudies-arrayexpress
TranscriptomicsThe microRNA-200 family regulates pancreatic beta-cell survival in type 2 diabetes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-05-06 | E-GEOD-58505 | biostudies-arrayexpress
TranscriptomicsExtrinsic and Intrinsic Regulation of DOR/TRP53INP2 Expression in Mice
The objective is to relate changes in expression of DOR/TRP53INP2, a factor involved in thyroid hormone action and autophagy, to body composition in mice fed a fat (FD) or high fat diet (HFD) for 8 days and in a genetically obese mouse model. We conclude that DOR expression depends on sex, fat conte...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-32872 | biostudies-arrayexpress
TranscriptomicsValproic acid achieves its anticancer activity by re-expression of cyclin D2
In this study we could show that the treatment of primary murine prostate cancer(PCa) cells derived from the well-established TRAMP (transgenic adenocarcinoma ofmouse prostate) model with the histone deacetylase inhibitor (HDI) valproic acid (VPA) has an anti-proliferative, anti-migrative and anti-i...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-34072 | biostudies-arrayexpress
TranscriptomicsSoybean toxin (SBTX) impairs fungal growth by interfering with molecular transport, carbohydrate/amino acid metabolism and drug/stress responses
Soybean toxin (SBTX) is an antifungal protein from soybeans with broad growth and filamentation inhibitory activity against many fungi, including human and plant pathogenic species such as Candida albicans, Candida parapsilosis, Aspergillus niger, Penicillium herquei, Cercospora sojina, and Cerospor...
ORGANISM(S): Candida albicans 
2013-12-31 | E-GEOD-47364 | biostudies-arrayexpress
TranscriptomicsOxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
To identify the detailed molecular causes of the mitochondrial dysfunction, oxidative burden and more vulnerable redox balance in Rett mouse hippocampus, we screened for differential gene expression in the hippocampal CA1 subfield of adult male mice. A whole mouse genome microarray was performed to ...
ORGANISM(S): Mus musculus 
2012-08-31 | E-GEOD-32870 | biostudies-arrayexpress
TranscriptomicsImpaired Chromatin Remodelling at STAT1-Regulated Promoters Leads to Global Unresponsiveness of Toxoplasma gondii-Infected Macrophages to IFN-Gamma
Intracellular pathogens including the apicomplexan and opportunistic parasite Toxoplasma gondii profoundly modify their host cells in order to establish infection. We have shown previously that intracellular T. gondii inhibit up-regulation of regulatory and effector functions in murine macrophages (...
ORGANISM(S): Mus musculus 
2012-01-25 | E-GEOD-28499 | biostudies-arrayexpress
TranscriptomicsMale-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6
Organic anion transporters 1 (Oat1) and 3 (Oat3) play a critical role in transport of organic anions, including frequently prescribed drugs, across cell membranes in proximal tubules of kidneys. In rats, these transporters are known to be male-predominant and testosterone dependently expressed. The ...
ORGANISM(S): Rattus norvegicus 
2012-04-17 | E-GEOD-34565 | biostudies-arrayexpress
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