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TranscriptomicsSphere-Derived Multipotent Progenitor Cells Obtained From Human Oral Mucosa Are Enriched in Neural Crest Cells.
The purpose of this study was to isolate NCSCs from oral mucosa using the neurosphere technique. Total RNA from human oral mucosa stromal cells and sphere-formig oral mucosa stromal cells was collected and compared at their gene expression level. Samples from 3 patients were analysed.
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-68636 | biostudies-arrayexpress
TranscriptomicsExamining smoking-induced differential gene expression changes in buccal mucosa
A tissue like buccal mucosa (from cheek swabs) would be an ideal sample material for rapid, easy collection for testing of biomarkers as an alternative to blood. A limited number of studies, primarily in the smoker/oral cancer literature, address this tissue's efficacy for quantitative PCR or micro...
ORGANISM(S): Homo sapiens 
2010-03-07 | E-GEOD-16149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human patients with acute myeloid leukemia and chemotherapy-induced oral mucositis
Chemotherapy may cause DNA damage within the oral mucosa of cancer patients leading to mucositis, a dose-limiting side effect for effective cancer treatment. We used whole genome gene expression analysis to identify cellular damage to the mucosal tissue occuring two days post induction chemotherapy ...
ORGANISM(S): Homo sapiens 
2009-01-14 | E-GEOD-10746 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of a wound healing process in skin and oral mucosa
When compared to skin, oral mucosal wounds heal rapidly and with reduced scar formation. This study used an Affymetrix microarray platform to compare the transcriptomes of oral mucosa and skin wounds in order to identify critical differences in the healing response at these two sites. Using microarr...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-23006 | biostudies-arrayexpress
TranscriptomicsAberrant lncRNA expression profiles in OSCC tissues compared with paired normal oral mucosa
Hypoxic microenvironment plays important roles in the progression of solid tumors including oral squamous cell carcinoma (OSCC). Long noncoding RNAs (lncRNAs) have gained much attention in the past few years. However, it is not clear whether lncRNAs could regulate hypoxia-adaptation of OSCC, and whi...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-84805 | biostudies-arrayexpress
ProteomicsLabel free proteomics of oral mucosa tissue to identify potential biomarkers that can flag predilection of precancerous lesions to oral cell carcinoma: A Preliminary study
Oral squamous cell carcinomas are neoplasms that are mostly preceded by precancerous lesions such as leukoplakia and erythroplakia. It is important for the clinician to know about the predilection and possibility of these precancerous conditions transforming to cancer. This will inturn help to effic...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037660 | Pride
Erythroplakia Malignant transformation Label-free proteomics Oxidative stress Oral squamous cell carcinoma Leukoplakia Differentially expressed proteins 
TranscriptomicsExpression Profiling of Oral Squamous Cell Carcinoma and Mucosa of healthy non-tumor patients
In an attempt to further elucidate the pathomechanisms in oral squamous cell carcinoma (OSCC), gene expression profiling to a set of 35 primary OSCCs compared to 6 oral mucosa from healthy non-tumor patients was performed. Keywords: expression profiling Gene expression profiling using a whole-transc...
ORGANISM(S): Homo sapiens 
2008-01-12 | E-GEOD-10121 | biostudies-arrayexpress
TranscriptomicsExpression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes
Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls. To identify genes whose transcription is d...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31853 | biostudies-arrayexpress
TranscriptomicsMethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients
This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress
TranscriptomicsGene expression in human oral mucosal fibroblasts and patient-matched skin fibroblasts
Wound healing within the oral mucosa results in minimal scar formation compared to wounds within the skin. We have recently demonstrated distinct differences in the ageing profiles of cells (oral mucosal and patient-matched skin fibroblasts) isolated from these tissues. We hypothesize that the incre...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21648 | biostudies-arrayexpress
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