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MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
MetabolomicsImpact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolite Composition

Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and infertility. Recently, the gut has been...

2025-11-07 | MTBLS12603 | MetaboLights
ProteomicsUltra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
The oral cavity is home to one of the most diverse microbial community of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions including lubrication of food, predigesting and bacterial defense. Consequently, disruptions in saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080862 | MassIVE
GenomicsTreponema medium strain:human oral | isolate:human oral
Treponema medium strain:human oral | isolate:human oral Genome sequencing
PRJNA482935 | ENA
ProteomicsOpportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors
Mechanisms by which Porphyromonas gingivalis (P. gingivalis) infection enhances oral tumor growth or resistance to cell death remain elusive. Here, we determined that P. gingivalis infection mediates therapeutic resistance via inhibiting lethal mitophagy in cancer cells and tumors. Mechanistically, ...
ORGANISM(S): Porphyromonas gingivalis Homo sapiens (Human) 
2024-06-23 | PXD051568 | Pride
Therapeutic resistance Oral cancers Ceramide  ceramide-dependent mitophagy  sphingolipid metabolism  oral infection  oral microbiota 
ProteomicsHuman dental calculus LC-MS/MS
The purpose of this study was to investigate oral microbiome and host proteins in archaeological human dental tissues using a shotgun proteomics approach. The research focuses on dental calculus (mineralized plaque), dentine, a carious lesion, and an alveolar bone abscess from the medieval site of D...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Homo Sapiens (ncbitaxon:9606) Ovis (ncbitaxon:9935) 
2016-10-23 | MSV000080279 | MassIVE
ModelsMazumdar2008 - Genome-scale metabolic network of Porphyromonas gingivalis (iVM679)
Mazumdar2008 - Genome-scale metabolic network of Porphyromonas gingivalis (iVM679) This model is described in the article: Metabolic network model of a human oral pathogen. Mazumdar V, Snitkin ES, Amar S, Segrè D. J. Bacteriol. 2009 Jan; 191(1): 74-90 Abstract: The ...
2015-07-30 | MODEL1507180038 | BioModels
ProteomicsThe Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis
Porphyrmonas gingivalis is an oral pathogen associated with the inflammatory disease periodontitis. The colonization of oral epithelial surfaces by P. gingivalis may also lead to the autoimmune disease rheumatoid arthritis. One of the hallmarks of rheumatoid arthritis is the loss of tolerance agains...
ORGANISM(S): Porphyromonas gingivalis 
2018-02-28 | PXD003444 | Pride
Porphyromonas gingivalis Mass spectrometry Citrullination Exoproteome Rheumatoid arthritis Periodontitis 
ProteomicsConnections between exoproteome heterogeneity and virulence in the oral pathogen Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative bacterial pathogen associated with severe periodontitis and non-oral diseases. Clinical isolates of Aa display a rough (R) colony phenotype with strong adherent properties. Upon prolonged culturing, non-adherent strains with a smooth (S) ...
ORGANISM(S): Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) 
2022-06-01 | PXD028940 | Pride
Aggregatibacter actinomycetemcomitans Virulence Exoproteome Serotype 
UnknownOral pathogen aggravates atherosclerosis by inducing smooth muscle cell apoptosis and repressing macrophage efferocytosis.
Not available
S-EPMC10307898 | biostudies-literature
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