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ProteomicsProtein citrullination in human tissues
Citrullination is a post-translational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations and while the modification has been linked to several diseases including rheumatoid arthritis a...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD008970 | Pride
Citrullination Post-translational modification Peptidylarginine deiminase Human proteome Synthetic peptides 
ProteomicsCharacterization of Citrullination Sites in Neutrophils and Mast Cells Activated by Ionomycin via Integration of Mass Spectrometry and Machine Learning
Citrullination is an important post-translational modification implicated in many diseases including rheumatoid arthritis (RA), Alzheimer's disease and cancer. Neutrophil and mast cells have different protein-arginine deiminases expression profile and ionomycin induced activation make them the ideal...
ORGANISM(S): Homo sapiens (Human) 
2022-01-12 | PXD023131 | Pride
Citrullination Mass spectrometry Mast cells Neutrophils 
ProteomicsA streamlined data analysis pipeline for the identification of sites of citrullination
Citrullination is an enzyme-catalyzed post-translational modification (PTM) that is essential for a host of biological processes including gene regulation, programmed cell death, and organ development. While this PTM is required for normal cellular functions, aberrant citrullination is a hallmark of...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD027358 | Pride
Citrullination 
ProteomicsHuman cytomegalovirus-induced host protein citrullination is crucial for viral replication
Citrullination is the conversion of arginine-to-citrulline by protein arginine deiminases (PADs), whose dysregulation is implicated in the pathogenesis of various types of cancers and autoimmune diseases. Consistent with the ability of human cytomegalovirus (HCMV) to induce post-translational modifi...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD025803 | Pride
Hcmv Ifit1 Citrullination 
ProteomicsCitrullination of glucokinase is linked to autoimmune diabetes
Inflammation, including reactive oxygen species and inflammatory cytokines in tissues amplify various post-translational modifications (PTMs) of self-proteins. A number of PTMs have been identified as autoimmune biomarkers in the initiation and progression of Type 1 diabetes (T1D). In this study, ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028825 | Pride
Post-translational modifications Type 1 diabetes Glucokinase 
ProteomicsNeutrophil-derived PAD4 induces citrullination of CKMT1 in epithelial cells to exacerbate mucosal inflammation
Objective Increased neutrophil extracellular trap-osis (NETosis) is a hallmark of inflammatory bowel disease (IBD). However, the mechanisms of NETosis formation and its detrimental effect on the intestinal epithelium remain poorly understood. Design Dextran sulfate sodium (DSS) induce colitis in pep...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD041504 | Pride
Peptidyl-arginine deiminase-4  citrullination  mitochondrial creatine kinase 1  neutrophil extracellular traps  intestinal epithelial cells  inflammatory bowel disease 
ProteomicsProtein citrullination and homocitrullination profiling in mice using LC-MS/MS
Citrullination and homocitrullination are two post-translational modifications (PTMs) that may cause protein structural and functional changes. Although they have been linked to various biological processes and disease development, the understanding is still poor because of limitations to enrich, de...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD023733 | Pride
Citrullination Mouse Biotin thiol tag Homocitrullination Lc-ms/ms 
ProteomicsCitrullination of latency-associated peptide of TGF beta1
Enzymatic citrullination of latency-associated peptide of TGF beta1 by PAD2
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080224 | MassIVE
ProteomicsPAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
The formation of elastic fibers is active only in the perinatal period. How elastogenesis is developmentally regulated is not fully understood. Citrullination is a unique form of post-translational modification catalyzed by peptidylarginine deiminases (PADIPADs), including PADIPAD1-4. Its physiologi...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-22 | PXD026238 | Pride
Deiminase Elastic fiber Citrullination Deimination Lung compliance Fibulin-5 
TranscriptomicsCitrullination of Histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma
Multiple myeloma (MM), an incurable plasma cell malignancy, requires localisation within the bone marrow in order to survive and proliferate. Interactions between the malignant plasma cell and bone marrow mesenchymal stem cell (BMMSC) are thought to be a critical determinant of this requirement, and...
ORGANISM(S): Homo sapiens 
2016-08-03 | E-GEOD-80608 | biostudies-arrayexpress
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