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ProteomicsIntegrative analysis of proteomics and DNA methylation in orbital fibroblasts from Graves
Graves’ ophthalmopathy (GO) is an extrathyroidal complication of Graves’ hyperthyroidism. Orbital fibroblast, an important cell in the pathogenesis of GO, is responsible for GO characteristics during active and inactive stages; however, information on the extensive profiles and the mechanistic regul...
ORGANISM(S): Homo sapiens (Human) 
2021-01-27 | PXD022257 | Pride
: graves’ ophthalmopathy Proteomics Orbital fibroblast Epigenetics Dna methylation 
TranscriptomicsscRNAseq of cell from orbital fat in thyroid eye disease
scRNAseq of thyroid eye disease orbital fat demonstrates fibroblast thyroid hormone signaling and SPARC production Orbital fat from four people undergoing decompression surgery for TED was digested to single cells and sequenced. Two donors' cells were hashed and combined into each sample. (i.e. fou...
ORGANISM(S): Homo sapiens 
2026-06-26 | E-MTAB-16698 | biostudies-arrayexpress
GenomicsscRNAseq of cell from orbital fat in thyroid eye disease
scRNAseq of cell from orbital fat in thyroid eye disease
PRJEB108944 | ENA
UnknownButyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Not available
S-EPMC11892527 | biostudies-literature
UnknownEZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves' ophthalmopathy.
Not available
S-EPMC10994939 | biostudies-literature
UnknownSOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway.
Not available
S-EPMC10866156 | biostudies-literature
GenomicsBulk RNA-seq data of orbital fibroblasts and peripheral blood mononuclear cells (PBMCs) from thyroid eye disease patients
Bulk RNA-seq data of orbital fibroblasts and peripheral blood mononuclear cells (PBMCs) from thyroid eye disease patients
PRJNA1176489 | ENA
TranscriptomicsIL-11 is elevated and drives the profibrotic phenotype transition of orbital fibroblasts in thyroid-associated ophthalmopathy [scRNA-seq]
Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression pattern of IL-11 in patients with TAO and whe...
ORGANISM(S): Homo sapiens 
2022-01-28 | GSE194323 | GEO
TranscriptomicsIL-11 is elevated and drives the profibrotic phenotype transition of orbital fibroblasts in thyroid-associated ophthalmopathy [RNA-seq]
Orbital fibrosis is a hallmark of tissue remodeling in thyroid-associated ophthalmopathy (TAO). Previous studies have shown that interleukin (IL)-11 plays a pivotal profibrotic role in various inflammatory and autoimmune diseases. However, the expression pattern of IL-11 in patients with TAO and whe...
ORGANISM(S): Homo sapiens 
2022-01-28 | GSE194322 | GEO
GenomicsIL-11 is elevated and drives the profibrotic phenotype transition of orbital fibroblasts in thyroid-associated ophthalmopathy [RNA-seq]
IL-11 is elevated and drives the profibrotic phenotype transition of orbital fibroblasts in thyroid-associated ophthalmopathy [RNA-seq]
PRJNA800326 | ENA
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