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ProteomicsSynaptosomal proteome from schizophrenia patients
Proteomic characterization of the synaptosome fraction of the orbitofrontal cortex using label-free and iTRAQ labeling strategies.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-30 | MSV000086389 | MassIVE
TranscriptomicsTranscription profiling of human prefrontal cortex during postnatal development
Fresh frozen post mortem prefrontal cortex tissue (Brodman area 46) was obtained from 44 individuals varying in age from 0 to 49 years. RNA was extracted from these samples and hybridized to HG133plus2.0 GeneChips. The data was used to examine patterns of gene expression over the course of human pos...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-13564 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal corte...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-5389 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prefrontal cortex of C57Bl/6J mice at Zeitgeber Time (ZT) 3, 9, 15, and 21.
Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9471 | biostudies-arrayexpress
GenomicsDevelopmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex
We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-21172 | biostudies-arrayexpress
TranscriptomicsWhole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
Whole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
ORGANISM(S): Homo sapiens 
2012-09-19 | E-MTAB-812 | biostudies-arrayexpress
ProteomicsPresynaptic proteins in the orbitofrontal cortex predict Alcohol Use Disorder
Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences, which are driven by dysfunction of cortical areas, such as the orbitofrontal cortex (OFC), that normally balances deci...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD041727 | Pride
Machine learning Alcohol drinking Isobaric labeling Alcohol use disorder Sexual dimorphism Mass spectrometry Ap2a1 Orbitofrontal cortex Mitochondria Quantitative proteomics Presynapses Extracellular matrix 
Genomicscircular Neurexin3 knockdown in rat orbitofrontal cortex
circular Neurexin3 knockdown in rat orbitofrontal cortex
PRJNA933181 | ENA
TranscriptomicsProfiling Transcriptomic Alterations in Postmortem Prefrontal Cortex Tissues of Individuals with Alcohol Use Disorders
Analysis of transcriptiomic alternations related with alcohol use disorders (AUDs). The hypothesis is that chronic alcohol consumption might alter genome-wide gene expression patterns. The results suggest that differential gene expression in the prefrontal cortex is implicated in neuroadaptations to...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49376 | biostudies-arrayexpress
TranscriptomicsTemporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex
In order to gain a global molecular perspective on how the human genome gives rise to the brain, we explore the temporal dynamics and genetic control of transcription in human dorsolateral prefrontal cortex in an extensive series of brain tissue from fetal development through aging. We discover a wa...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-30272 | biostudies-arrayexpress
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