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UnknownFlotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes.
Not available
S-EPMC7396279 | biostudies-literature
ProteomicsDNAJC5 facilitates the proliferation and migration of lung adenocarcinoma cells by augmenting EGFR trafficking
Lung adenocarcinoma (LUAD) is a highly prevalent and lethal malignant tumor, with the aberrantly activated EGFR signaling pathway playing a crucial role in its development. However, resistance to tyrosine-kinase inhibitors (TKIs) targeting EGFR significantly limits the efficacy of LUAD clinical ther...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD063682 | Pride
Dnajc5 Ap2a1 Luad Egfr Endocytosis 
ProteomicsPresynaptic proteins in the orbitofrontal cortex predict Alcohol Use Disorder
Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences, which are driven by dysfunction of cortical areas, such as the orbitofrontal cortex (OFC), that normally balances deci...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD041727 | Pride
Machine learning Alcohol drinking Isobaric labeling Alcohol use disorder Sexual dimorphism Mass spectrometry Ap2a1 Orbitofrontal cortex Mitochondria Quantitative proteomics Presynapses Extracellular matrix 
UnknownAP2A1 activates Rab7 to promote axonal autophagosome transport and slow the progression of Alzheimer's disease.
Not available
S-EPMC12147321 | biostudies-literature
UnknownAlpha adaptins show isoform-specific association with neurofibrillary tangles in Alzheimer's disease.
Not available
S-EPMC8810620 | biostudies-literature
UnknownAdaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.
Not available
S-EPMC10918038 | biostudies-literature
UnknowncircEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer.
Not available
S-EPMC10492306 | biostudies-literature
ProteomicsAffinity AP2 Proteomics Fragile X
Fragile X syndrome (FXS), the most common inherited intellectual disability and monogenic cause of autism, results from loss of FMRP, which regulates mRNA translation essential for brain development and synaptic plasticity. FMRP has been implicated in the synaptic localization and surface expression...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD065502 | Pride
Proteomics Ap2 
TranscriptomicsWhole genome landscapes of major melanoma subtypes
Cutaneous, acral and mucosal subtypes of melanoma were evaluated by whole-genome sequencing, revealing genes affected by novel recurrent mutations to the promoter (TERT, DPH3, OXNAD1, RPL13A, RALY, RPL18A, AP2A1), 5’-UTR (HNRNPUL1, CCDC77, PES1), and 3’-UTR (DYNAP, CHIT1, FUT9, CCDC141, CDH9, PTPRT)...
ORGANISM(S): Homo sapiens 
2017-12-01 | GSE80435 | GEO
UnknownFMRP-dependent translational control negatively regulates adapter protein complex 2-mediated endocytosis.
Not available
S-EPMC12307669 | biostudies-literature
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