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TranscriptomicsInduction of target genes of AP2-Sp in AP2-O::Sp parasites
Sporozoite-specific genes were induced in parasites that express AP2-O whose AP2 domain was swapped with that of AP2-Sp. DNA construct encoding AP2 domain of AP2-Sp was introduced into P. bergei schizonts. It was integrated into the locus of the endogenious AP2-O gene, resulting in swap of the AP2-...
ORGANISM(S): Plasmodium berghei 
2010-06-20 | E-GEOD-18910 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mammary epithelial cells over-expressing AP2
BACKGROUND: The AP2 transcription factor family is a set of developmentally regulated, retinoic acid (RA) inducible genes, which regulate expression of estrogen receptor-alpha (ERalpha) in breast carcinoma. We hypothesized that AP2 factors regulate a set of genes characteristic of the hormone respon...
ORGANISM(S): Homo sapiens 
2007-05-03 | E-SMDB-4003 | biostudies-arrayexpress
TranscriptomicsAP2 transcription factors regulate expression of CRABPII in hormone responsive breast carcinoma
BACKGROUND: The AP2 transcription factor family is a set of developmentally regulated, retinoic acid (RA) inducible genes, which regulate expression of estrogen receptor-alpha (ERalpha) in breast carcinoma. We hypothesized that AP2 factors regulate a set of genes characteristic of the hormone respon...
ORGANISM(S): Homo sapiens 
2007-08-09 | E-GEOD-7616 | biostudies-arrayexpress
GenomicsOrchestration of development by the bifunctional transcription factor, APETALA2
The emerging picture of transcriptional regulation is one of unexpected complexity. It is now clear that single transcription factors control hundreds, if not thousands, of direct targets by binding their genomic loci, but it is not understood how many of these are major players and how many are sup...
ORGANISM(S): Arabidopsis thaliana 
2010-04-13 | E-GEOD-21301 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals
Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ„¢ arrays,...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9130 | biostudies-arrayexpress
ProteomicsThe interactome of the clathrin adaptor AP2 is modulated by the phosphorylation status of its µ2 subunit.
The clathrin adaptor AP2 is phosphorylated at a single site (Thr156) of its µ2 subunit. To gain insight how phosphorylation influences the interactome of AP2, we used human RPE cells which that were treated with LP-935509, an inhibitor of the adaptor-associated kinase AAK1. Kinase inhibition and los...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD013468 | Pride
Receptor Endocytosis Clathrin Aak1 Necap 
GenomicsPFG controls gene expression in female gametocytes cooperatively with AP2-FG [AP2-FG_DIP]
PFG controls gene expression in female gametocytes cooperatively with AP2-FG [AP2-FG_DIP]
PRJNA938389 | ENA
TranscriptomicsThe Submergence Tolerance Regulator Sub1A Mediates Stress-responsive Expression of AP2/ERF Transcription Factors
Rice NSF45K microarray experiment to dissect submergence tolerance response in submergence tolerant rice plant, M202(Sub1): We previously characterized the rice (Oryza sativa L.) Sub1 locus encoding three Ethylene Responsive Factor (ERF) transcriptional regulators. Genotypes carrying the Sub1A-1 a...
ORGANISM(S): Oryza sativa 
2010-03-08 | E-GEOD-17704 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in ap2-g and ap2-g2 mutants of Plasmodium berghei
Commitment to and completion of sexual development are essential for malaria parasites to be transmitted through mosquitoes. The molecular mechanism(s) responsible for these processes however, remain largely unknown. We have identified two transcription factors (both belonging to the AP2 family) ess...
ORGANISM(S): Plasmodium berghei 
2013-12-03 | E-GEOD-52859 | biostudies-arrayexpress
GenomicsVascular tumor spectrum in aP2-Cre mice
Vascular tumor spectrum in aP2-Cre mice
PRJNA790670 | ENA
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