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TranscriptomicsMsi1 integrates APC loss and mTORC1 activation to promote intestinal stem cell transformation
Loss of the APC tumor suppressor in the intestinal epithelium initiates the majority of human colorectal adenocarcinomas. Constitutive β-catenin activation is thought to underlie tumorigenesis induced by loss of APC, however β-catenin activation alone does not recapitulate all APC-loss phenotypes,...
ORGANISM(S): Mus musculus 
2015-10-22 | E-GEOD-54598 | biostudies-arrayexpress
TranscriptomicsTransformation of the intestinal epithelium by the MSI2 RNA binding protein
The MSI2 RNA binding protein has recently emerged as a potent oncogene playing key roles in hematopoietic stem cell homeostasis and malignant hematopoiesis. Here we demonstrate that MSI2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinom...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-64388 | biostudies-arrayexpress
TranscriptomicsChildren's Oncology Group Study 9906 for High-Risk Pediatric ALL
PAPER 1:"Identification of novel subgroups of high-risk pediatric precursor B acute lymphoblastic leukemia (B-ALL) by unsupervised microarray analysis: clinical correlates and therapeutic implications. A Children's Oncology Group (COG) study." ABSTRACT We examined gene expression profile...
ORGANISM(S): Homo sapiens 
2009-06-25 | E-GEOD-11877 | biostudies-arrayexpress
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