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MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
MetabolomicsMolecular basis for multidrug efflux by an anaerobic-associated RND transporter

Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
MetabolomicsA female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite
ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametoc...
2016-09-14 | MTBLS98 | MetaboLights
MetabolomicsA metabolomics dataset of plankton exometabolomes and dissolved organic compounds in the South Atlantic Ocean

The marine microbiome contributes to nearly half of our planet’s net primary production. It plays a central role in the ocean’s carbon cycle through both passive and active release of metabolites into seawater, forming a pool of dissolved compounds known as the marine exometabolome.


2026-05-19 | MTBLS14508 | MetaboLights
MetabolomicsBio-organic fertilizer alleviates tobacco continuous cropping obstacles by coordinately reprogramming plant metabolism and the rhizosphere microbiome
Background Crop continuous cropping obstacles (CCO) severely threaten soil ecosystem health and sustainable agricultural production. Although bio-organic fertilizer (BF) has been widely applied to mitigate crop CCO, the underlying mechanisms remain poorly understood. Herein, an Aspergillus-amended B...
2026-04-13 | MTBLS14267 | MetaboLights
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
ProteomicsTranscriptomic and phosphoproteomic profiling and metabolite analyses reveal the mechanism of NaHCO3-induced organic acid secretion in grapevine roots
Organic acid secretion is a widespread physiological response of plants to alkalinity. However, the features of alkali-induced secretion of organic acid and the underlying mechanism are poorly understood. Herein, it was indicated that oxalate was the main organic acid synthesized and secreted in vin...
ORGANISM(S): Vitis vinifera (Grape) 
2019-11-11 | PXD013746 | Pride
Transcriptome Organic acid secretion Phosphoproteome Grapevine Alkali stress 
TranscriptomicsMale-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6
Organic anion transporters 1 (Oat1) and 3 (Oat3) play a critical role in transport of organic anions, including frequently prescribed drugs, across cell membranes in proximal tubules of kidneys. In rats, these transporters are known to be male-predominant and testosterone dependently expressed. The ...
ORGANISM(S): Rattus norvegicus 
2012-04-17 | E-GEOD-34565 | biostudies-arrayexpress
ProteomicsFunctional Response of Polar Bacterial Communities under Variable Organic Inputs Revealed with Metaproteomic, 16S rRNA and Organic Compositional Analysis
Organic matter recycling in marine systems is largely driven by microbial processes, particularly in the Arctic where primary production and inputs can be temporally offset from upper trophic level consumption. This study followed bacterial dynamics in the chlorophyll maximum of the Bering Strait an...
ORGANISM(S): marine metagenome 
2019-02-18 | PXD008780 | Pride
Metaproteomics Metagenomics Bacteria Arctic Organic matter 
TranscriptomicsTranscriptional response of Listeria monocytogenes h7858 and f6854 to lactate and acetate
The organic acids lactate and diacetate are commonly used in combination in ready-to-eat foods because they show synergistic, i.e. greater than additive, ability to inhibit the growth of Listeria monocytogenes. Full genome microarrays were used to investigate the synergistic transcriptomic response...
ORGANISM(S): Listeria monocytogenes 
2011-11-03 | E-GEOD-25195 | biostudies-arrayexpress
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