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GenomicsChIP-seq analysis of chromatin state plasticity in primary human adult erythroid progenitor cells
We report a computational approach for investigation of chromatin state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distribution of H3K27me3 in 19 human cell lines. We found that high plasticity regions (HPRs) can be divided into two funct...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-52924 | biostudies-arrayexpress
UnknownASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Not available
S-EPMC4930721 | biostudies-literature
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71422 | biostudies-arrayexpress
GenomicsPolycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, Enhancer of Zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine-27 of histone H3 (...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-25549 | biostudies-arrayexpress
UnknownEHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.
Not available
S-EPMC4608240 | biostudies-literature
UnknownThe CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo.
Not available
S-EPMC3434552 | biostudies-literature
UnknownInitiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.
Not available
S-EPMC4569751 | biostudies-literature
UnknownWhy START? Reflections that led to the conduct of this large long-term strategic HIV trial.
Not available
S-EPMC4347998 | biostudies-literature
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