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Hepatocyte-specific CEBPA-ORM1 axis restricts alcohol-associated liver disease
The alterations of gene expression profiling induced by ORM1 knockdown in HCT116 cells.
Alcohol-associated liver disease (ALD) affects millions of people worldwide, while pharmacological therapies are limited. CCAAT/enhancer binding protein α (CEBPA) in hepatocytes is known to regulate the progression of liver fibrosis; however, the role of hepatocyte-specific CEBPA in modulating the A...
ORGANISM(S): Mus musculus 
2026-03-03 | GSE291057 | GEO
Recently, ORM1 was found to play an oncogenic role in in several cancers. Here we report gene expression profiles of HCT116 cells treated with ORM1 siRNA. This study reveals a novel role of ORM1 in downstream gene regulation and provides a new explanation of ORM1’ s function in colorectal cancer.
ORGANISM(S): Homo sapiens 
2026-02-09 | GSE289217 | GEO
To identify the molecular targets of orosomucoid (Orm1) during liver regeneration, GeneChip analysis was performed at 48 h after partial hepatectomy (PH) in regenerating mouse liver treated with siControl or siOrm. A total of 180 differentially expressed genes in Orm1 konckdown mouse liver by compar...
ORGANISM(S): Mus musculus 
2016-07-01 | GSE83733 | GEO
To identify the molecular targets of orosomucoid (Orm1) during liver regeneration, GeneChip analysis was performed at 48 h after partial hepatectomy (PH) in regenerating mouse liver treated with siControl or siOrm. A total of 180 differentially expressed genes in Orm1 konckdown mouse liver by compar...
ORGANISM(S): Mus musculus 
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