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TranscriptomicsMolecular profiling of functional interactions between pre-osteoblastic and breast carcinoma cells
The relationships between cancer cells and the microenvironment play a critical role in cancer growth and development. The bone stroma consists of mesenchymal stem cells (MSCs) and mature osteoblasts that promote cancer growth. Yet it is not completely understood what are the molecular processes gui...
ORGANISM(S): Mus musculus 
2014-11-23 | E-GEOD-34529 | biostudies-arrayexpress
TranscriptomicsIsp7 is a novel regulator of amino acid uptake in the TOR signaling pathway
We show that the sensitivity of tsc mutant cells to rapamycin is mediated by TORC1 and can be suppressed by overexpression of the 2-oxoglutarate-Fe(II) dependent oxygenase, Isp7. We show that Isp7 is a novel regulator of amino acids uptake that acts via regulation of gene expression, both upstream a...
ORGANISM(S): Schizosaccharomyces pombe 
2014-02-05 | E-GEOD-52759 | biostudies-arrayexpress
TranscriptomicsPax6 is required for normal cell cycle exit and the differentiation kinetics of retinal progenitor cells.
The coupling between cell-cycle exit and onset of differentiation is a common feature throughout the developing nervous system, but the mechanisms that link these processes are mostly unknown. Although the transcription factor Pax6 was implicated in both proliferation and differentiation of multiple...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-45143 | biostudies-arrayexpress
TranscriptomicsInsulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro
Expansion of beta cells from the limited number of adult human islet donors is an attractive prospect for increasing cell availability for cell therapy of diabetes. However, while evidence supports the replicative capacity of adult beta cells in vivo, attempts at expanding human islet cells in tissu...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-30732 | biostudies-arrayexpress
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