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GenomicsThe Role of Orphan GPCR GPR153 in Regulating Vascular Damage Responses
The Role of Orphan GPCR GPR153 in Regulating Vascular Damage Responses
PRJNA1126670 | ENA
TranscriptomicsThe Role of Orphan GPCR GPR153 in Regulating Vascular Damage Responses
Expression of GPR153 is upregulated in response to damage both in smooth muscle cells and endothelial cells.We found knockdown of GPR153 in SMC reduced the ligation-induced neointima formation, and GPR153 defeciency in EC protect the mice from neuroinflammation. The mechanism of orphan GPCR GPR153 i...
ORGANISM(S): Homo sapiens 
2025-06-04 | GSE270457 | GEO
UnknownDecrypting orphan GPCR drug discovery via multitask learning.
Not available
S-EPMC10804799 | biostudies-literature
ProteomicsPost-translational modifications orchestrate the intrinsic signaling bias of orphan receptor GPR52
Despite recent advances in GPCR structure and pharmacology, the regulation of GPCR activation, signaling, and functioning by diverse post-translational modifications (PTMs) has been largely unexplored. Furthermore, for a special category of self-activating orphan GPCRs, it is completely unknown whet...
ORGANISM(S): Homo Sapiens 
2025-03-03 | PXD061422 |
UnknownCryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing.
Not available
S-EPMC11437087 | biostudies-literature
UnknownThe orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.
Not available
S-EPMC2987804 | biostudies-literature
UnknownStructure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
Not available
S-EPMC8611064 | biostudies-literature
UnknownOrphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling.
Not available
S-EPMC7211037 | biostudies-literature
UnknownGpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
Not available
S-EPMC8599615 | biostudies-literature
UnknownOrphan receptor ligand discovery by pickpocketing pharmacological neighbors.
Not available
S-EPMC5247308 | biostudies-literature
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