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MetabolomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
ProteomicsA genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication (NS4B Effectome - Global Proteome)
Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Despite the availability of few vaccines, no antiviral drugs are currently licensed for the treatment of orthoflavivirus infections. Several pre-clinical studi...
ORGANISM(S): Homo sapiens (Human) Orthoflavivirus 
2026-03-10 | PXD063404 | Pride
GenomicsOrthoflavivirus dengue
Orthoflavivirus dengue Assembly
PRJNA1365489 | ENA
GenomicsOrthoflavivirus denguei
Orthoflavivirus denguei Genome sequencing
PRJNA1348690 | ENA
GenomicsOrthoflavivirus nilense
Orthoflavivirus nilense Genome sequencing
PRJNA1320692 | ENA
GenomicsOrthoflavivirus denguei
Orthoflavivirus denguei Raw sequence reads
PRJNA1373386 | ENA
ProteomicsA genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication (NS4Bome)
Orthoflavivirus infections represent an increasing public health burden, with several members of the genus emerging or re-emerging globally. Despite the availability of few vaccines, no antiviral drugs are currently licensed for the treatment of orthoflavivirus infections. Several pre-clinical studi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD063343 | Pride
UnknownSubcellular determinants of orthoflavivirus protease activity.
Not available
S-EPMC12336820 | biostudies-literature
GenomicsGlycerophospholipid remodeling is critical for orthoflavivirus infection
Glycerophospholipid remodeling is critical for orthoflavivirus infection
PRJNA1101937 | ENA
GenomicsOrthoflavivirus
Flavivirus, Zika virus Genome sequencing and assembly
PRJNA394139 | ENA
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