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UnknownRituximab plus chlorambucil as first-line treatment for chronic lymphocytic leukemia: Final analysis of an open-label phase II study.
Not available
S-EPMC4876343 | biostudies-literature
GenomicsDAC of the chronic lymphocytic leukemia epigenome and transcriptome profiling project
Data Access Committee EGAC00001000486
EGAC00001000486 | EGA
GenomicsChromatin accessibility maps of chronic lymphocytic leukemia identify subtype-specific epigenome signatures and transcription regulatory networks
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
ORGANISM(S): Homo sapiens 
2016-06-26 | E-GEOD-81274 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (SNP data)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35329 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (expression)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35082 | biostudies-arrayexpress
TranscriptomicsINTEGRATIVE ONCOGENOMIC AND HIGH-THROUGHPUT SEQUENCING ANALYSES OF THE COMMONLY DELETED REGION IN CHROMOSOME 7q32 IN SPLENIC MARGINAL ZONE LYMPHOMA (CGH)
Using high-resolution genomic microarray analysis, a distinct genomic profile was defined in 114 samples from patients with splenic marginal zone lymphoma (SMZL). Notably, deletion or uniparental disomy of chromosome 7q were detected in 39% of SMZLs but in only 9 of 170 (5%) mature B-cell lymphomas ...
ORGANISM(S): Homo sapiens 
2012-07-31 | E-GEOD-35367 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD43+ cells isolated from myelodysplastic syndrome patients and normal controls reveals involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.
55 patients with MDS and 11 healthy controls were included in the study. At the time of investigation, 18 patients had RA, 19 RARS and 18 RAEB. The RAEB group was further subdivided into RAEB1 and RAEB2 for a selected part of the analysis. Bone marrow samples were obtained and CD34+ cells isolated f...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4619 | biostudies-arrayexpress
Genomicsena-DATASET-CeMM-13-05-2016-20:41:19:139-66 - samples
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
EGAD00001002110 | EGA
GenomicsEpigenome and transcriptome profiling of chronic lymphocytic leukemia patients
Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, we established genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using the ...
EGAS00001001821 | EGA
Genomics233fa72b-87ef-4a9b-b96d-dfb6ca9543bd - samples
This dataset contains the aligned whole genome sequencing data of cell line 380. This cell was established from the peripheral blood of a 15-year-old boy with acute lymphoblastic leukemia at relapse, showing an immature phenotype and carrying an IGH-MYC (t(8;14)) as well as an IGH-BCL2 (t(14;18)) ch...
EGAD00001004090 | EGA
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