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ProteomicsProteome profile of Traf6-OE OT-I T cells
Proteome profile of Traf6-OE OT-I T cells and EV OT-I cells after viral transfection
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039327 | Pride
Mouse Lc-ms Traf6-oe ot-i t cells 
TranscriptomicsGene expression by antigen activated OT-I T cells in vivo in the presence and absence of IL-2
Much is known concerning the cellular and molecular basis for CD8+ T memory immune responses. Nevertheless, conditions that selectively support memory generation have remained elusive. Here we show that an immunization regimen that delivers TCR signals through a defined antigenic peptide, inflammato...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39110 | biostudies-arrayexpress
GenomicsRNAseq of control OT-I cells and Eomes-overexpressing OT-I cells
RNAseq of control OT-I cells and Eomes-overexpressing OT-I cells
PRJNA506823 | ENA
Genomicsanti-Eomes ChIPseq of control OT-I cells and Eomes-overexpressing OT-I cells
anti-Eomes ChIPseq of control OT-I cells and Eomes-overexpressing OT-I cells
PRJNA506822 | ENA
TranscriptomicsRNAseq of memory cocktail versus IL-2 grown OT-I CD8 T cells
Cytotoxic T cells are typically expanded ex vivo for adoptive immunotherapy by culture with IL-2. This culture period leads to a differentiated phenotype and acquisition of effector function, as well as a loss of in vivo proliferative capability and anti-tumor efficacy. Here, we report antigen-spec...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-54877 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq OT-I Cd8 T cells
To better understand the mechanisms downstream of IL-27 signaling, we performed RNA sequencing on repetitively stimulated OT-I T cells treated with IL-27.
ORGANISM(S): Mus musculus 
2024-12-06 | E-MTAB-14580 | biostudies-arrayexpress
TranscriptomicsRedirection of therapeutic T cells to a bone marrow niche improves their persistence and anti-tumor functions: transcription profiling by array of resting memory OT-I T_CXCR4) or OT-I T_Control cells isolated from the spleen 90 days following DC vaccination.
This study reports the improvement in function and antitumor efficacy of CXCR4 overexpression in therapeutic CD8+ T cells. Polyclonal CD8+ T cells from OT-I C57BL/6 (B6) mice were transduced with a modified pMP71 retroviral vector containing murine Cxcr4 and Gfp reporter sequences (T_CXCR4) or with ...
ORGANISM(S): Mus musculus 
2018-03-28 | E-MTAB-6091 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of WT and Tfap4–/– OT-I cells activated by Listeria monocytogenes expressing ovalbumin
Gene expression of Tfap4–/– and WT OT-I T cells were compared 4 or 6 days after activation with Listeria monocytogenes infection in vivo with the ERCC spike-in RNA control. Naive CD8+ T cells from Tfap4–/– OT-I or control WT OT-I TCR transgenice mice were adoptively transferred to congenic host mice...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58076 | biostudies-arrayexpress
GenomicsGenome wide analysis of Open Chromatin Regions in memory OT-I cells
Genome wide analysis of Open Chromatin Regions in memory OT-I cells
PRJNA639157 | ENA
TranscriptomicsExpression data from OT-I CD8 T cells activated with DC in the presence or absence of CpG-Induced Inflammation
Inflammatory cytokines promote the accumulation of activated CD8 T cells. Here, we transfer 600 OT-I CD8 T cells iv into naïve C57BL/6 hosts. One day later, 500,000 LPS-matured and OVA257 peptide-coated DC were injected iv into OT-I CD8 T cell seeded hosts with (DC+CpG) or without (DC). Other se...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53200 | biostudies-arrayexpress
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