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Proteomics"Time-resolved quantitative proteomic analysis of the developing otic vesicle reveals putative congenital hearing loss candidates and a novel role for Tgfbi
A large number of congenital hearing loss cases have an unknown genetic etiology. So far, transcriptomic approaches have successfully identified many candidate regulators of otic development, little is known about the abundance of their protein products during the development of the inner eat. Herei...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-10-24 | PXD041991 | Pride
Otic development Congenital hearing loss Xenopus laevis Temporal Extracellular matrix 
TranscriptomicsExpression data from mesodermal Tbx1-knockout otic vesicles and periotic mesenchyme at E11.5
The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding periotic mesenchyme during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both auditory and vestibular systems. We have previously iden...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-34065 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse differentiating ventral otic Epithelial Cell line
The study of the gene expression during otic development is a source of important information for understanding the mechanism of inner ear development and subsequently create appropriate gene therapies both to prevent hearing loss and eventually to regenerate the damaged parts.This dataset contains ...
ORGANISM(S): Mus musculus 
2009-04-17 | E-GEOD-15585 | biostudies-arrayexpress
Transcriptomicsc-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells [RNA-Seq]
An immortalized multipotent otic progenitor (iMOP) cell was generated by transient expression of c-Myc in Sox2-expressing otic progenitor cells. The procedure activated endogenous c-Myc expression in the cells and amplified existing Sox2-dependent transcripts to promote self-renewal. Downregulation ...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-62512 | biostudies-arrayexpress
TranscriptomicsExpression data from mesodermal Tbx1-knockout otic vesicles at E11.5
The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding periotic mesenchyme during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both auditory and vestibular systems. We have previously iden...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-34064 | biostudies-arrayexpress
Genomicsc-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells [ChIP-Seq]
An immortalized multipotent otic progenitor (iMOP) cell was generated by transient expression of c-Myc in Sox2-expressing otic progenitor cells. The procedure activated endogenous c-Myc expression in the cells and amplified existing Sox2-dependent transcripts to promote self-renewal. Downregulation ...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-62513 | biostudies-arrayexpress
GenomicsHuman Pluripotent stem cells-derived Inner ear organoids recapitulate otic development in vitro
Human Pluripotent stem cells-derived Inner ear organoids recapitulate otic development in vitro
PRJNA953046 | ENA
TranscriptomicsBone signaling in rat middle ear and cochlea by transcription profiling
* Bone signaling in middle ear development *
Common middle ear diseases, such as chronic suppurative otitis media and cholesteatoma, may affect bone behavior in the middle ear air cell system.
This study analyzed gene expression of bone-related signaling factors and gene sets from lini...
ORGANISM(S): Rattus norvegicus 
2014-02-20 | E-MTAB-2336 | biostudies-arrayexpress
TranscriptomicsIdentification of downstream transcriptional targets of Dlx5 during early mouse inner ear (otocyst/otic vesicle) development
Several transcription factors are known to be expressed in discrete regions of the otic vesicle and Dlx5 is one of those that is expressed highly in the presumptive dorsal vestibular region. Mice lacking Dlx5 have vestibular defects. Specifically, they fail to form the endolymphatic duct (a defect v...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-22381 | biostudies-arrayexpress
UnknownOtic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development.
Not available
S-EPMC3160092 | biostudies-literature
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