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TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [iCLIP-Seq]
iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies. iCLIP was performed in duplicates using RBFOX2 and CPSF2 antibodies.
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60385 | biostudies-arrayexpress
TranscriptomicsGlobal Regulation of Alternative Internal Exon Usage by mRNA 3' End Formation Factors [RNA-Seq]
RNA-seq analysis of samples from Non-silencing, RBFOX2 and CPSF2 knockdown cells We analyzed 6 samples using the Illumina HiSeq 2000. Sequence data was processed by DexSeq. Two biological replicates were performed for Non-silencing, RBFOX2 and CPSF2 knockdown cells
ORGANISM(S): Homo sapiens 
2015-07-15 | E-GEOD-60391 | biostudies-arrayexpress
GenomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity
We performed ChIP-seq to chart genome-wide maps of H3K27me3 in brown preadipocytes and mature brown adipocytes. We observed a subset of brown fat-specific genes, but not common fat genes or white fat-specific genes, possess the H3K27me3 mark in preadipocytes, and this mark is erased in mature adipoc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-55469 | biostudies-arrayexpress
TranscriptomicsJmjd3-mediated H3K27me3 dynamics orchestrate brown fat cell fate transition and regulate white fat plasticity (RNA-Seq)
We performed RNA-Seq for brwon fat, epididymal white fat and soleus muscle of mice to identify brown fat-selective, white fat-selective and common fat genes. RNA-Seq for brown fat, white fat and soleus muscle of wild type C56BL6 mice.
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-56367 | biostudies-arrayexpress
TranscriptomicsmiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-39983 | biostudies-arrayexpress
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