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UnknownA Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?
Not available
S-EPMC6044500 | biostudies-literature
UnknownCDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells.
Not available
S-EPMC3092200 | biostudies-literature
UnknownFrom Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.
Not available
S-EPMC4862455 | biostudies-literature
UnknownTargeting low molecular weight cyclin E (LMW-E) in breast cancer.
Not available
S-EPMC3855283 | biostudies-literature
UnknownCDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Not available
S-EPMC4087096 | biostudies-literature
UnknownNovel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation.
Not available
S-EPMC6421297 | biostudies-literature
UnknownThe toll-like receptor agonist imiquimod is active against prions.
Not available
S-EPMC3745460 | biostudies-literature
UnknownStructural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models.
Not available
S-EPMC6491434 | biostudies-literature
UnknownA Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment.
Not available
S-EPMC6981120 | biostudies-literature
ProteomicsExtended proteomes of brain organ from individual neonatal rats for understanding hypoxia–ischemia-related brain Injury and drug action.
Next-generation shotgun proteomics of brain organ from individual neonatal rats suffering hypoxia-ischemia related brain injury in order to assess their response to a novel pharmaceutical drug.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-13 | PXD050059 | Pride
Drug Injury Brain Ischemia Proteomics Encephalopathy Molecular pathways Hypoxia 
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