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MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
MetabolomicsAnalysis of flavor formation and metabolite changes during production of buffalo milk Double-Layer Steamed Milk Custard

Metabolomics analysis showed that concentration of free amino acids and short-chain fatty acid lipids were increased in DLSMC, and they were more easily digested and absorbed. Key metabolic pathways, including alanine, aspartate, and glutamate metabolism, starch and sucrose metabolism, and glycer...

2025-08-23 | MTBLS12717 | MetaboLights
ProteomicsThe puzzling construction of the conidial outer layer of Aspergillus fumigatus
The outer layers of the fungal cell wall are the first barrier facing external challenges. In theinvasive morphotype of the airborne pathogen Aspergillus fumigatus, i.e. conidia, the outer cell wall consists of α-(1,3)-glucan, melanin and proteinaceous rodlets made up by the RodA hydrophobin. The h...
ORGANISM(S): Aspergillus fumigatus CEA10 
2019-01-30 | PXD011734 | Pride
Conida Aspergillus fumigatus Out layer 
TranscriptomicsMulti-layer omics dataset for cross-species translational systems biology
Inferring in humans biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine and cannot be easily studied in humans. Thus, biomedical research has continuously relied on animal models for studying the impact of these compounds and ...
ORGANISM(S): Rattus norvegicus 
2014-06-10 | E-MTAB-2091 | biostudies-arrayexpress
MetabolomicsMetabolic Remodeling of Soil Ecosystems by the medicinal fungus Wolfiporia cocos: Bidirectional Feedback and Functional Consequences
Widely targeted metabolomics based on UPLC-MS/MS was performed to explore metabolic differences between two tissues of Wolfiporia cocos sclerotium. Samples include inner white tissue (Fuling Bai) and outer layer (Fuling Pi) of sclerotium, with 3 biological replicates for each group. A total of 1565 ...
2027-08-10 | MTBLS15360 | MetaboLights
TranscriptomicsGene expression of cerebellar granule cell layer
We performed gene-expression analysis of mouse cerebellar granule cell layer as compared to that of Purkinje cells. DNA microarray analysis detected genes in cerebellar granule cell layer, most of which are classified into functional molecule categories. Our comparative analysis between Purkinje cel...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-26750 | biostudies-arrayexpress
TranscriptomicsExpression data from Amacr knock-out mouse intestine
Bile acids play multiple roles in vertebrate metabolism by facilitating lipid absorption in the intestine and acting as a signaling molecule in lipid and carbohydrate metabolism. Bile acids are also the main route to excrete excess cholesterol out of the body. Alpha-methyl-Coa racemase (Amacr) is on...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-40124 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human embryonic stem cells (hESC) line Amicqui-1 derived and maintained on human amniotic epithelial cells
Conventional conditions to maintain human embryonic stem cells (hESC) imply the use of inactive mouse embryonic fibroblast (iMEF) as a feeder layer. However, it has suggested that the culture of hESC on iMEF could be an artifact that does not correspond to the in vitro counterpart of the human epibl...
ORGANISM(S): Homo sapiens 
2022-05-01 | E-MTAB-10347 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of CD34+ thymocytes that were cultured on an OP9-GFP or OP9-DLL1 feeder layer.
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-62000 | biostudies-arrayexpress
TranscriptomicsSystematic analysis of miRNA transcriptome of skeletal muscle identifies novel miRNAs and differentially expressed miRNAs in divergent skeletal muscle growth rates of broiler and layer chickens
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Gallus gallus 
2011-03-18 | E-GEOD-20992 | biostudies-arrayexpress
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