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MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
ProteomicsProteome profiling of ovarian cancer and cirrhosis ascites
Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication http://www.mcponline.org/content/early/2014/09/30/mcp.M114.041194.full.pdf+html?sid=78e7a955-fa54-4ded-b296-89f1fb6adbec
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079934 | MassIVE
TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
ProteomicsGlycomic and proteomic analyses of malignant ascites fluid were used to identify potential metastatic biomarkers of epithelial ovarian cancer : Partial
Ovarian cancer is a major cause of cancer mortality among women largely due to late diagnosis of advanced stage metastatic disease. More extensive molecular analysis of metastatic ovarian cancer is needed to identify post-translational modifications of proteins particularly associated with metastati...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD003794 | Pride
Ascites Concanavalin a Epithelial ovarian cancer 
OtherProteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication.
Data from ProteomeXchange, PXD ID: PXD001403. File: V022-V023+V053_line8_MGFPeaklist.mgf. Published as part of Mol Cell Proteomics. 2014 Sep 30 . From the Abstract: {{i}} The aim of this study was to elucidate specific features of malignant ascites metabolome and proteome. To omit components that b...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210030783 | GPMDB
Resource Reanalysis 
TranscriptomicsA platform of patient-derived tumor xenografts (EOC-xenografts) to recapitulate the clinicopathology and genetic alterations of ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. On the basis of its histopathology and molecular-genomic changes ovarian cancer has been divided into subtypes, each with distinct biology and outcome. The aim of this study was to develop a panel of patient-derived EOC-xen...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-56920 | biostudies-arrayexpress
ProteomicsProteome profiling of microvesicles, exosomes and supernatant from SKOV3
Proteome-metabolome profiling of ovarian cancer ascites reveals novel components involved in intercellular communication http://www.mcponline.org/content/early/2014/09/30/mcp.M114.041194.full.pdf+html?sid=78e7a955-fa54-4ded-b296-89f1fb6adbec
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079992 | MassIVE
TranscriptomicsGene expression profile of ascites cell samples from patients with advanced ovarian cancer
We present evidence for an autocrine cytokine network in human ovarian cancer that has paracrine actions on the tumour microenvironment. In experiments using bioinformatics analysis of large gene expression array datasets and ovarian cancer biopsies, we found that the inflammatory cytokines TNF-α an...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-18681 | biostudies-arrayexpress
TranscriptomicsMixed-polarization phenotype of ascites-associated macrophagesin human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse
Ascites-associated macrophages were collected from human ovarian carcinoma patients and their expression profiles determined via Agilent microarrays. In addition, monocyte derived macrophages from healthy donors were differentiated ex-vivo with MCSF and GMCSF and their expression profiles determined...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-MTAB-1661 | biostudies-arrayexpress
ProteomicsProteome profiles of paired ovarian cancer ascites before and after chemotherapy
Ovarian cancer is characterized by transcoelomic metastasis into the peritoneal cavity. The peritoneal malignant ascites is enriched with ovarian cancer cells and a small amount of tumor-associated immune cells which create a unique microenvironment actively contributing to progression of the diseas...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD019327 | Pride
Ovarian cancer ascites Combinatorial peptide libraries Therapy-induced secretome 
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