Sort   by:  
 Page size 
MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
MetabolomicsSphingosine-1-phosphate receptor 1 promotes ovarian cancer tumorsphere proliferation and metastasis
Despite extensive clinical endeavors to enhance high-grade serous ovarian cancer (HGSOC) detection and treatment, an alarming half of diagnosed women succumb annually to this disease. Significantly, nearly all HGSOC cases manifest ascites at diagnosis, a poor prognostic indicator. Malignant ascites ...
2026-03-04 | MTBLS13770 | MetaboLights
MetabolomicsTargeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase inhibitors (PARPi), such as olaparib, have significantly improved outcomes in ovarian cancer (OC); however, therapy resistance remains a major clinical challenge. Here, we showed that glutamine metabolism was upregulated in PARPi-resistant OC cells and identified the g...

2026-04-08 | MTBLS14072 | MetaboLights
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses
This SuperSeries is composed of the following subset Series: GSE15350: Resistance of primary ovarian cancer cells to oncolytic adenoviruses part1 of 2 GSE15351: Resistance of primary ovarian cancer cells to oncolytic adenoviruses part2 of 2 Refer to individual Series
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-15473 | biostudies-arrayexpress
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses part2 of 2
The mechanisms of primary ovarian cancer cells for resistance to viral oncolysis were investigated using Ad5/35.IR.E1A/TRAIL on clonal cultures derived from ovc316m cells. Part 2 of 2, 26 clonal ovc316m cultures additionally to Resistance of primary ovarian cancer cells to oncolytic adenoviruses par...
ORGANISM(S): Homo sapiens 
2009-04-01 | E-GEOD-15351 | biostudies-arrayexpress
TranscriptomicsResistance of primary ovarian cancer cells to oncolytic adenoviruses part1 of 2
The mechanisms of primary ovarian cancer cells for resistance to viral oncolysis were investigated using Ad5/35.IR.E1A/TRAIL on clonal cultures derived from ovc316m cells. Part 1 of 2, initital study involving 5 clonal ovc316m cultures Cells were infected for 8 days and cell survival determined by M...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-15350 | biostudies-arrayexpress
TranscriptomicsAscites enriches for ovarian cancer stem-like cells that express membrane GRP78
Ovarian cancer patients are generally diagnosed at stage III/IV, when ascites is common. The volume of ascites positively correlates with the extent of metastasis and negatively with prognosis. Membrane GRP78, a stress-inducible endoplasmic reticulum chaperone which also appears on the plasma membra...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-61285 | biostudies-arrayexpress
TranscriptomicsRepertoire of miRNAs in epithelial ovarian cancer determined by next generation sequencing of small RNA cDNA libraries
Background: MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which improved outcomes could be achieved by successful early detectio...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15190 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after RNA interference of CXCR4 in human ovarian cancer cell line IGROV-1.
In the past three years the role of inflammatory cytokines and chemokines in tumour promotion and progression has been intensively studied. The chemokine receptor CXCR4 and its ligand CXCL12 are commonly expressed in malignant cells from primary tumours, metastases and also in malignant cell lines. ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13763 | biostudies-arrayexpress
Sort   by:  
 Page size