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MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
MetabolomicsUridine Attenuates Osteoclastogenesis and Ovariectomy Induced Bone Loss by Modulating the PI3K/Akt–FoxO ROS Signaling Axis

Osteoporosis is a metabolic bone disorder characterized by aberrant osteoclast activation, leading 

to excessive bone resorption and microarchitectural deterioration. Although the interconnection 

between osteoclast differentiation and cellular energy metabolism has been inc...

2026-04-09 | MTBLS13394 | MetaboLights
Genomicsovariectomy of mouse contents
ovariectomy of mouse contents Raw sequence reads
PRJNA1031711 | ENA
TranscriptomicsTranscription profiling of uterine horns from SvJ/129 mice treated with progesterone to study the progesterone-mediated roles of Hoxa-10 in preimplantation uterus.
This SuperSeries is composed of the following subset Series: GSE106: OVX/P4/UTX 129/SvImJ WT A; GSE107: OVX/P4/UTX 129/SvImJ WT B Experiment Overall Design: Refer to individual Series. Female mice used were 129/SvImJ wildtype (Jackson Lab), 10-16 weeks of age. 14 days after ovariectomy, mice were in...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of uterine horns from Hoxa-10+/+ and Hoxa-10-/- SvJ/129 mice treated with or without progesterone to study the progesterone-mediated roles of Hoxa-10 in preimplantation uterus.
This SuperSeries is composed of the following subset Series:; GSE108: OVX/P4/6h/UTX 129 WT vs. Hoxa-10-/-; GSE109: OVX/oil/6h/UTX 129 WT vs. Hoxa-10-/- Experiment Overall Design: Refer to individual Series. Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6439 | biostudies-arrayexpress
ProteomicsOmental adipose tissue metaboproteome: differential dysregulation by chronic binge alcohol and ovariectomy in simian immunodeficiency virus-infected female macaques
Effective antiretroviral therapy (ART) has significantly reduced mortality of people living with HIV (PLWH). Increased survival and aging of PLWH is associated with increased incidence of at-risk alcohol use and of metabolic comorbidities; and in women, menopause may be an additional factor contribu...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2022-08-12 | PXD023076 | Pride
Adipose alcohol ovariectomy siv macaques lc-ms tmtpro 
GenomicsGene expression changes in femur tissues of ovariectomy-induced osteoporosis rats
Gene expression changes in femur tissues of ovariectomy-induced osteoporosis rats
PRJNA832613 | ENA
TranscriptomicsGene expression profiles of PDX models with acquired resistance to endocrine treatments
Acquired resistance to endocrine therapy occurs with high frequency in patients with luminal breast cancer (LBC). We report here the establishment of four patient-derived xenograft models of LBC with acquired resistance in vivo to tamoxifen and estrogen deprivation. CEL files represent expresison da...
ORGANISM(S): Homo sapiens 
2014-07-09 | E-GEOD-55561 | biostudies-arrayexpress
TranscriptomicsMicroarray transcriptome profile of perimetrial adipose tissue in female HHTG rats - sham-operated, ovariectomized and ovariectomized with estradiol treatment
The study aimed to analyse the effect of ovariectomy and estradiol substitution in a prediabetic model with insulin resistance – females of the hereditary hypertriglyceridemic rat strain (HHTg).
ORGANISM(S): Rattus norvegicus 
2024-07-31 | E-MTAB-13224 | biostudies-arrayexpress
GenomicsmicroRNA expression in sham and ovariectomy (OVX) mice femur tissue
microRNA expression in sham and ovariectomy (OVX) mice femur tissue
PRJNA431766 | ENA
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