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MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
TranscriptomicsOVCAR-3 Cells: Control vs. FBA-TPQ treated
The study was designed to determine the biological effects of novel marine alkaloid analog, FBA-TPQ on human ovarian cancer cells for its anti-tumor potential and the underlying mechanisms as a novel chemotherapeutic agent. Transcriptional profiling of human ovarian cancer cells comparing control ve...
ORGANISM(S): Homo sapiens 
2011-11-12 | E-GEOD-25317 | biostudies-arrayexpress
TranscriptomicsA2780 and OVCAR-3 Cells:Control vs. LS-98 treated
Transcriptional profiling of human ovarian cancer cells comparing control vehicle-treated A2780 and OVCAR-3 (Human ovarian cancer cell lines) cells with A2780 and OVCAR-3 cells treated with 5μM LS-98 for 24 hours.Goal was to determine the effects of LS-98 compound on the global A2780 and OVCAR-3 ce...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29668 | biostudies-arrayexpress
TranscriptomicsExpression data from OVCAR-3 cells overexpressing histone H1.3
Ovarian cancer is a deadly gynecological malignancy for which novel biomarkers and therapeutic targets are imperative for improving survival. To investigate the role of histone H1 in ovarian cancer cells, we overexpress a histone H1 variant, H1.3, in the OVCAR-3 epithelial ovarian cancer cell line. ...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-61692 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48919 | biostudies-arrayexpress
TranscriptomicsCopy number analysis of OVCAR-3 and CDK2 resistant sublines
Cyclin E1 (CCNE1) is amplified in various tumor types including high-grade serous ovarian cancer where it is associated with poor clinical outcome. We have demonstrate that suppression of the Cyclin E1 partner kinase, CDK2, induces apoptosis in a CCNE1 amplicon-dependent manner. Little is known of m...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48920 | biostudies-arrayexpress
TranscriptomicsTranscriptional patterns associated with OvCar-3 cells in response to osteopontin-c splicing isoform overexpression
We previously demonstrated that the osteopontin-c (OPNc) splice variant activates several aspects of the progression of ovarian cancers. The goal of the present study was to develop cell line model to determine the impact of OPNc overexpression on main cancer signaling pathways and thus obtain insig...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-57888 | biostudies-arrayexpress
ProteomicsInward outward signaling in ovarian cancer: morpho-proteomics/phosphoproteomics profiling upon hypoxia and shear stress characterizes the adaptive potential of OVCAR-3 and SKOV-3 cells
With the onset of resistance, ovarian cancer cells display almost unpredictable adaptive potential. This may derive from genetic ancestry of the tumor cells and can be additionally tailored by post translational protein modifications (PTMs). The latter are profoundly shaped by the physical and chemi...
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD027466 | Pride
Hypoxia Vasculogenic mimicry Fluid shear stress Morpho-metabolic adaptation Ovarian cancer 
GenomicsGene expression in NIH:OVCAR-3 cells treated with chemotherapeutic drugs
Gene expression in NIH:OVCAR-3 cells treated with chemotherapeutic drugs
PRJNA1398863 | ENA
TranscriptomicsExpression data from OVCAR-3 cells overexpressing histone H1.3
Ovarian cancer is a deadly gynecological malignancy for which novel biomarkers and therapeutic targets are imperative for improving survival. To investigate the role of histone H1 in ovarian cancer cells, we overexpress a histone H1 variant, H1.3, in the OVCAR-3 epithelial ovarian cancer cell line. ...
ORGANISM(S): Homo sapiens 
2014-10-31 | GSE61692 | GEO
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