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MetabolomicsCell overgrowth potentiates osmotic and replication stresses to promote p38/p53/p21-dependent senescence
Abnormal increases in cell size are associated with senescence and cell cycle exit. The mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain unknown. We address this question using CDK4/6 inhibitors, which arrest cells in G0/G1 and are licensed to treat advanced HR+/HER...
2025-10-24 | MTBLS8698 | MetaboLights
MetabolomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response and chronic p38MAPK activation to promote long-term cell cycle arrest

Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibito...

2025-10-24 | MTBLS5868 | MetaboLights
MetabolomicsCross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition
Not available
ORGANISM(S): Bacteroides spp. and Escherichia spp. (mixed communities) 
ST001862 | MetabolomicsWorkbench
TranscriptomicsThyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity
This study investigates the development of adipose tissue before birth which is crucial for energy storage and thermogenesis in the neonatal period, and for long term metabolic health. The design uses the thyroid deficiency sheep fetus examined at two different gestational ages.
ORGANISM(S): Ovis aries 
2020-03-31 | E-MTAB-8396 | biostudies-arrayexpress
TranscriptomicsNPA-induced vascular overgrowth in Arabidopsis
We used N-(1-naphthyl) phthalamic acid (NPA)-induced vascular overgrowth in Arabidopsis leaves to look for differential up-regulation of genes in NPA-treated tissues that may be involved in vascular differentiation. Arabidopsis thaliana Col-0 plants were grown for approximately 2 weeks on solid ATS ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-05 | E-GEOD-19262 | biostudies-arrayexpress
GenomicsSegmental overgrowth/vascular anomalies/dermatologic disorders
Segmental overgrowth/vascular anomalies/dermatologic disorders
PRJNA623429 | ENA
GenomicsSegmental overgrowth/vascular anomalies/dermatologic disorders
Segmental overgrowth/vascular anomalies/dermatologic disorders
PRJNA623430 | ENA
ProteomicsRpS19a depletion alters the haematopoietic translatome to directly drive tissue overgrowth
Counterintuitively, increased tumour predisposition is associated with ribosomal protein (RP) loss. Here, we provide the first evidence that RP depletion can directly drive tissue overgrowth. Haematopoietic compartment-specific knockdown (KD) of RpS19a in the Drosophila lymph gland not only results ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-08-13 | PXD043115 | Pride
Haematopoiesis Drosophila Ribosomal protein Translation 
ProteomicsCDK4/6 inhibitor-mediated cell overgrowth triggers an osmotic stress response
Cell size and the cell cycle are intrinsically coupled and abnormal increases in cell size are associated with senescence and permanent cell cycle arrest. The mechanism by which overgrowth primes cells to withdraw from the cell cycle remains unknown. We investigate this here using CDK4/6 inhibitors ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD036519 | Pride
Lc-ms/ms Dia Cell growth Cell cycle 
TranscriptomicsContributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip.
A human gut-on-a-chip microdevice was used to coculture multiple commensal microbes in contact with living human intestinal epithelial cells for more than a week in vitro and to analyze how gut microbiome, inflammatory cells, and peristalsis-associated mechanical deformations independently contribut...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-65790 | biostudies-arrayexpress
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