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UnknownNanoscale clustering of carbohydrate thiols in mixed self-assembled monolayers on gold.
Not available
S-EPMC3350752 | biostudies-literature
TranscriptomicsRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Recently, we defined four subtypes of pancreatic cancer that are associated with distinct histopathological characteristics and differential survival, namely, Squamous, Pancreatic Progenitor, Immunogenic, and ADEX (Bailey et al 2016, Nature). We also found that loss of CXCR2 was associated with a sw...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-6620 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse astrocytes in monoculture and co-cultured with rat neurons (both inactive and active).
Neurons induce a dramatic transformation in developing astrocytes, causing them to develop a complex stellate morphology resembling their appearance in vivo. However, the transcriptional changes that accompany this transformation are not known, nor are the signalling mechanisms responsible. Similarl...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-MTAB-5514 | biostudies-arrayexpress
Unknown561. Safety of Remdesivir vs Standard Care in Patients with Moderate Covid-19
Not available
S-EPMC7777368 | biostudies-literature
TranscriptomicsRNA-seq of triple cultures of neurons, astrocytes and microglia treated with blood clot conditioned media, lipopolysaccharide, and Nrf2-activating drug CDDO-TFEA.
Secondary injury causes death and dependence after spontaneous intracerebral haemorrhage (ICH). We found that myelomononuclear Nrf2 is active and protective after ICH in mice. To investigate the roles of myelomononuclear Nrf2 in modulating cell autonomous and non-cell autonomous responses to the oxi...
ORGANISM(S): mixed sample 
2024-08-13 | E-MTAB-14327 | biostudies-arrayexpress
TranscriptomicsSingle-cell sequencing of FACS-sorted mouse astrocytes, investigating the effect of absence of microglia in a mouse model of ß-amyloidopathy
The APPSwe/PS1dE9 (APP/PS1) mouse ß-amyloidopathy mouse model exhibits extracellular Aß deposition, particularly in the neocortex and hippocampus, increasing steadily from about 6 months, with reactive astrogliosis and synapse loss occurring proximal to plaques. We crossed APP/PS1 mice onto genetica...
ORGANISM(S): Mus musculus 
2024-10-15 | E-MTAB-14233 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse brain tissue investigating the effect of absence of microglia in a mouse model of ß-amyloidopathy
The APPSwe/PS1dE9 (APP/PS1) ß-amyloidopathy mouse model exhibits extracellular Aß deposition increasing steadily from about 6 months, particularly in the neocortex and hippocampus, with reactive astrogliosis and synapse loss occurring proximal to plaques. We crossed APP/PS1 mice onto genetically mod...
ORGANISM(S): Mus musculus 
2024-10-15 | E-MTAB-14231 | biostudies-arrayexpress
TranscriptomicsTRAP-seq of astrocytes in the APP NL-F knock-in model of ß-amyloidopathy
While mouse models of ß-amyloidopathy recapitulate aspects of Alzheimer's disease pathology, including plaque formation and synapse loss, most progress at a speed such that outcomes are studied in the mature mouse, rather than the aged mouse. Here we investigated Aß-dependent changes to astrocytes i...
ORGANISM(S): Mus musculus 
2024-03-21 | E-MTAB-13936 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse T3-L1 preadipocytes treated with the steroid hormone dexamethasone in biological and technical replicates to illustrate validation methods
DNA microarrays are popular tools for measuring gene expression of biological samples. This ever increasing popularity is ensuring that a large number of microarray studies are conducted, many of which with data publicly available for mining by other investigators. Under most circumstances, validati...
ORGANISM(S): Mus musculus 
2006-07-28 | E-MEXP-774 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 23 human nevi with a pool of primary cutaneous melanoma
Genomic profiles comparing 23 nevi with a pool of primary cutaneous melanoma
ORGANISM(S): Homo sapiens 
2009-04-16 | E-TABM-3 | biostudies-arrayexpress
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