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ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021631 | Pride
Arid1a depeltion Ip-ms Mesc 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021624 | Pride
Ip-ms Mesc Arid1a depletion 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021824 | Pride
Arid1a depeltion Ip-ms Mesc Swi/snf 
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021636 | Pride
Tmt Mesc Arid1a depletion 
GenomicsA role for Snf2 related nucleosome spacing enzymes in genome-wide nucleosome organization
The positioning of nucleosomes within the coding regions of eukaryotic genes is aligned with respect to transcriptional start sites. This organization is likely to influence many genetic processes, requiring access to the underlying DNA. Here we show that the combined action of Isw1 and Chd1 nucleos...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-16 | E-GEOD-31015 | biostudies-arrayexpress
ProteomicsAcute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for EP300 dependent activation and repression of transcription.
The ARID1A subunit of the SWI/SNF chromatin remodelling complex is one of the most frequently mutated tumour suppressors. Here, a degron system is applied to detect rapid loss of chromatin accessibility at thousands of loci that frequently include binding sites for pluripotency transcription factors...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD021623 | Pride
Arid1a Tmt Ip-ms Mesc 
GenomicsLandscape of protein SUMOylation on chromatin in hIPSCs (ChiPS4) by SUMO1 CHIP-seq
SUMO1 CHIP-seq experiment was performed in untreated hiPSC line - ChiPS4, to determine the exact locations of chromatin bound SUMO1 in these cells, thus providing information about the landscape of SUMOylation of protein targets on chromatin in human pluripotent cells and as such allowing for invest...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9960 | biostudies-arrayexpress
TranscriptomicsInfluence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9962 | biostudies-arrayexpress
TranscriptomicsInfluence of SUMOylation on chromatin structure in hIPSCs (ChiPS4) assessed by time-resolved ATAC-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9961 | biostudies-arrayexpress
UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
Not available
S-EPMC11408082 | biostudies-literature
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