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MetabolomicsLow-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)
This study investigated the effects of low-temperature stress on the brain metabolome of juvenile fourfinger threadfin (Eleutheronema tetradactylum). Using UHPLC-Q-TOF-MS-based untargeted metabolomics, we analyzed brain tissues from fish exposed to 28°C (control) and 18°C for 7 and 14 days. The aim ...
2026-07-22 | MTBLS15103 | MetaboLights
MetabolomicsLactobacillus plantarum MR1 alleviates high-carbohydrate diet-induced oxidative stress and liver lipid deposition via upregulating uridine synthesis
The overconsumption of carbohydrates induces oxidative stress and lipid accumulation in the liver, which can be alleviated by modulation of intestinal microbiota; however, the underlying mechanism remains unclear. Here, we demonstrated that a strain affiliated with Lactobacillus plantarum (de...
2024-01-16 | MTBLS4262 | MetaboLights
TranscriptomicsExosomes mediate protective messages during oxidative stress; role of exosomal shuttle RNA
Exosomes are small extracellular nano-vesicles of endocytic origin that mediate different signals between cells, by surface interactions and by shuttling of functional RNA from one cell to another. In this study, we show that exosomes, produced by mouse mast cells exposed to oxidative stress, change...
ORGANISM(S): Mus musculus 
2011-01-07 | E-GEOD-24886 | biostudies-arrayexpress
TranscriptomicsMicroarray based analysis of temperature and oxidative stress induced messenger RNA in Schistosoma mansoni
The body’s defense against schistosome infection can take many forms. For example, upon developing acute schistosomiasis, patients often have fever coinciding with larval maturation, migration and early oviposition. As the infection becomes established, the parasite comes under oxidative stress gene...
ORGANISM(S): Schistosoma mansoni 
2008-08-25 | E-GEOD-11706 | biostudies-arrayexpress
Models,MultiomicsOxidative Stress Pathway
Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress ...
3512 | Cell Collective
ProteomicsOxidative stress induced ADP-ribosylome
Oxidative stress is a potent inducer of protein ADP-ribosylation. Although the proteins modified under oxidative stress have been identified, it is not clear, whether the number of modified proteins and/or the number ADP-ribosylation sites varies with stress intensity. Here, we investigated both the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-11-13 | MSV000080334 | MassIVE
MetabolomicsEnhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids
The notion that plants use specialized metabolism to protect against environmental stresses needs to be experimentally proven by addressing the question of whether stress tolerance by specialized metabolism is directly due to metabolites such as flavonoids. We report that flavonoids with radical sca...
2013-12-06 | MTBLS57 | MetaboLights
MetabolomicsMetabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating long-term multisystem disorder with a central and inexplicably persistent fatigue symptom that is unable to be relieved by rest. Energy metabolism and oxidative stress have been recent focal points of ME/CFS research and i...
2015-06-08 | MTBLS161 | MetaboLights
MetabolomicsMulti-omics reveals taurine-mediated rumen microbial remodeling mitigates high-starch-diet-induced systemic inflammation and oxidative stress in fattening cattle

Background: With the pursuit of rapid intramuscular fat deposition in beef cattle, basal diets have increasingly shifted toward grain-based, energy-dense formulations. However, high-starch dietary regimens may induce host metabolic dysregulation, which is closely linked to both ruminal microbial ...

2025-09-25 | MTBLS13041 | MetaboLights
MetabolomicsPlasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.

OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and an established natural animal model for human epilepsy types with genetic and unknown etiology. However, the metabolic pathways underlying IE remain largely unknown. METHODS: Plasma samples of healthy...

2025-07-02 | MTBLS10915 | MetaboLights
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