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TranscriptomicsTranscription profiling of macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) to evaluate the gene expression profile in presence and absence of oxidized LDL
Total RNA pools from macrophages from Familial Hypercholesterolemia(FH) patients with tendon xanthomas (TX+) and without tendon xanthomas (TX-) were analyzed using Affymetrix oligonucleotide arrays (HGU133A) to evaluate the gene expression profile in presence and absence of oxidized LDL.
ORGANISM(S): Homo sapiens 
2006-01-01 | E-MEXP-360 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of UV- or oxidized lipid treated dermal skin fibroblasts
Long wavelength Ultraviolet (UVA-1) radiation causes oxidative stress that leads to the formation of noxious substances within the skin. As a defensive mechanism skin cells produce detoxifying enzymes and antioxidants when they detect modified molecules. We have recently shown that UVA-1 irradiation...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13606 | biostudies-arrayexpress
TranscriptomicsGene expression in primary human macrophages and foam cells
The aim of the experiment was to determine the effects of 48 hours of treatment with oxidized low density lipoprotein (oxLDL) on gene expression in primary human monocyte-derived macrophages. 6 independent biological replicates were processed. From each replicate half of the cells were treated with ...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54666 | biostudies-arrayexpress
TranscriptomicsHydrogen modulates signal transduction through manipulating oxidized phospholipid mediators
We have previously demonstrated that molecular hydrogen (H2) neutralizes hydroxyl radical (M-bM-^@M-"OH) in cultured-cells and protects cells and tissues against oxidative stress. Growing evidence has confirmed that H2-consumption exhibits preventive and therapeutic effects in patients with various...
ORGANISM(S): Homo sapiens 
2014-10-17 | E-GEOD-62434 | biostudies-arrayexpress
GenomicsChromatin immunoprecipitation with next generation sequencing (ChIP-seq) of H3K27ac in primary human macrophages and foam cells
We report the enhancer landscape in primary human macrophages and foam cells using ChIP-seq for the H3K27ac histone mark CD14+ monocytes were isolated from the blood of 2 healthy male volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stim...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54972 | biostudies-arrayexpress
GenomicsFormaldehyde-assisted isolation of regulatory elements with next generation sequencing (FAIRE-seq) in primary human macrophages and foam cells
We report the open chromatin landscape in primary human macrophages and foam cells using FAIRE-seq CD14+ monocytes were isolated from the blood of 3 healthy volunteers. Monocytes were differentiated into macrophages by culture for 7 days with 50ng/ml macrophage colony stimulating factor and then tre...
ORGANISM(S): Homo sapiens 
2015-04-08 | E-GEOD-54971 | biostudies-arrayexpress
ProteomicsAn RNA granule for translation quality control in Saccharomyces cerevisiae
Cytoplasmic RNA granules compartmentalize phases of the translation cycle in eukaryotes. We previously reported the localization of oxidized RNA to cytoplasmic foci called oxidized RNA bodies (ORBs) in human cells. We show here that ORBs are RNA granules in Saccharomyces cerevisiae. Several lines of...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-11-23 | PXD037184 | Pride
Translation. Rna granules Oxidized rna Ribosome-associated quality control No-go decay 
TranscriptomicsTranscriptional study of oxLDL-induced foam cell formation in WT and Atf3-/- murine bone marrow macrophages
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-loaded macrophages in the arterial wall. Intimal macrophages internalize modified lipoproteins such as oxidized LDL (oxLDL) through scavenger receptors, leading to storage of excess cholesteryl esters in lip...
ORGANISM(S): Mus musculus 
2012-03-23 | E-GEOD-32358 | biostudies-arrayexpress
ProteomicsIdentification of 8-oxoG binding proteins in Deinococcus radiodurans
8-oxo-7,8-dihydroguanine (8-oxoG) is a common RNA oxidation that has been implicated in carcinogenesis, neurodegeneration, and aging. Some? Many? RNA-binding proteins have shown binding preference for 8-oxoG modified RNA; such binding? can protect cells from oxidative stress. To date, the presence o...
ORGANISM(S): Deinococcus radiodurans ATCC 13939 
2022-07-10 | PXD028861 | Pride
8-oxo-7 8-dihydroguanine  rna oxidation  rna binding proteins  pnpase  rhlb  oxidative stress  deinococcus radiodurans  rna degradation 
GenomicsThe contribution of RNA oxidation to acute kidney injury: evidence from ISG20-mediated oxidized RNA degradation
The contribution of RNA oxidation to acute kidney injury: evidence from ISG20-mediated oxidized RNA degradation
PRJNA939512 | ENA
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