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TranscriptomicsISR target genes in the liver of mock-injected and AP20187-treated mice of wildtype and Atf4-/- genotype
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2α (eIF2α)-specific phosphatase, GADD34, was used to selectively comp...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11116 | biostudies-arrayexpress
TranscriptomicsISR target genes in the liver of either LFD and HFD-treated Alb::GC mice and AP20187-treated TTR::Fv2E-PERK mice
The molecular mechanisms linking the stress of unfolded proteins in the endoplasmic reticulum (ER stress) to glucose intolerance in obese animals are poorly understood. In this study enforced expression of a translation initiation 2alpha (eIF2a)-specific phosphatase, GADD34, was used to selectively ...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-11210 | biostudies-arrayexpress
TranscriptomicsDevelopment of mRNA and miRNA expression signatures of MEFs deficient in ER stress mediators for tunicamycin treatment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35209 | biostudies-arrayexpress
TranscriptomicsISR target genes revealed by comprehensive microarray network study using Perk -/-, Atf4 -/-, eIF2a S51A mutant, Fv2E-PERK
To identify the target genes of integrated stress reponse (ISR), we have employed whole genome microarray expression in MEF cells. ISR gene setimation under ER stress condition using Perk -/-, Atf4 -/-, eIF2a S51A mutant, Fv2E-PERK MEF cells
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-49598 | biostudies-arrayexpress
TranscriptomicsISR target genes in WAT and BAT of mAP::Fv2E-PERK
To identify the target genes of integrated stress reponse (ISR) in WAT and BAT, we have employed whole genome microarray expression in WAT and BAT specific Fv2E-PERK transgenic mice. The mAP::Fv2E-PERK transgenic mice were injected by AP20187 or mock.
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-49645 | biostudies-arrayexpress
TranscriptomicsSaturated fatty acids induced genes and ISR target genes in pancreatic beta cells
To identify the genes induced by lipotoxicity and integrated stress response in pancreatic beta cells, we have employed whole genome microarray expression in panvreatic beta cell line MIN6m9 cells. First microarray analysis : Wild type MIN6m9 cells were treated with Palmitate, Oleate or negative con...
ORGANISM(S): Mus musculus 
2015-08-01 | E-GEOD-49647 | biostudies-arrayexpress
TranscriptomicsGene expression profile of ATF6a and ATF6b overexpression in LS174T cells
To further development of our mRNA expression approach to ER stress, we have employed whole genome microarray expression profiling as a discovery platform to identify ER stress-responsible genes. LS174T cells were overexpressed with ER stress mediators, ATF6a or ATF6b. Genes responsible for each med...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-49567 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator ATF6a for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator ATF6a were treated with tunicamycin for ...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35176 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator XBP1 for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator XBP1 were treated with tunicamycin for 1...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35174 | biostudies-arrayexpress
TranscriptomicsDevelopment of miRNA expression signatures of MEFs deficient in a ER stress mediator ATF4 for tunicamycin treatment
To further development of our miRNA expression approach to ER stress, we have employed miRNA microarray expression profiling as a discovery platform to identify ER stress-responsible ones. Mouse embryonic fibroblasts (MEFs) deficient in a ER stress mediator ATF4 were treated with tunicamycin for 1...
ORGANISM(S): Mus musculus 
2015-01-18 | E-GEOD-35175 | biostudies-arrayexpress
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