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ProteomicsAn integrative transcriptomic and proteomic analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus
Clavulanic acid is a clinically-important secondary metabolite used in treatment of infectious diseases. We aimed to decipher complex regulatory mechanisms acting in clavulanic acid biosynthesis through the analysis of transcriptome- and proteome-wide alterations in an industrial clavulanic acid ove...
ORGANISM(S): Streptomyces clavuligerus 
2022-11-02 | PXD032272 | Pride
Streptomyces clavuligerus depa Rna seq Nanolc-ms/ms Clavulanic acid overproduction 
ProteomicsProtocol for cell surface biotinylation of magnetic labeled and captured human peripheral blood mononuclear cells
Analysis of the surfaceome of a blood cell subset requires cell sorting, followed by surface protein enrichment. Here, we present a protocol combining magnetically activated cell sorting (MACS) and surface biotinylation of the target cell subset from human peripheral blood mononuclear cells (PBMCs)....
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD038027 | Pride
Macs Surface proteome Biotinylation 
ProteomicsA Subtractive Proteomics Approach for the Identification of Immunodominant Acinetobacter baumannii Vaccine Candidate Proteins
Background: Acinetobacter baumannii is one of the most dangerous multidrug-resistant pathogens worldwide. Currently, 50-70% of clinical isolates of A. baumannii are extensively drug-resistant (XDR) and available antibiotic options against A. baumannii infections are limited. There are still needs to...
ORGANISM(S): Acinetobacter baumannii AYE Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 
2022-11-02 | PXD037507 | Pride
Immunodominant Vaccine candidate Immunoprecipitation Acinetobacter baumannii (a. baumannii) Proteomics 
ProteomicsProteomic and biological analysis of metformin senomorphics effects on the mesenchymal stromal cells
Senotherapeutics are new drugs, which can modulate senescence phenomena within tissues and reduces the onset of age-related pathologies. Senotherapeutics are divided in senolytics and senomorphics. The senolytics kill selectively senescent cells, while the senomorphics may delay or block the onset o...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028349 | Pride
Mesenchymal stromal cells  senescence  senolytics  senomorphics 
ProteomicsComparative Proteomic Analysis of Dental-Origin Stem Cells: Insights into Regenerative Potential
Teeth are a significant source of stem cells and have clinical importance for regenerative medicine. A human tooth harbors different kinds of stem cells in the dental pulp (DPSC) or the periodontal ligament (PDLSC). Also exfoliated teeth in childhood contain a special type of stem cells in their pul...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD058096 | Pride
Proteome Pdlsc Dpsc Secretome Shed 
ProteomicsMesenchymal Stem Cells of Adipose Tissue Prone to Lose Their Stemness in Obesity Associated Stress Conditions
Obesity is a health problem characterized by large expansion of adipose tissue. During this expansion, genotoxic stressors can be accumulated and negatively affect the Mesenchymal Stem Cells (MSCs) of adipose tissue. Due to the oxidative stress generated by these genotoxic stressors, senescence phen...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050811 | Pride
Obesity Stemness Senescence 
ProteomicsTooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles
Tooth decay, also known as dental caries, is a prevalent oral health problem that significantly reduces an individual's quality of life; however, it can be effectively managed through restorative treatments. The condition primarily affects the enamel and dentin structures and can be treated before i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD064565 | Pride
Dental caries Senescence Tooth decay Dpsc 
ProteomicsMyeloma cancer cells can corrupt mesenchymal stromal senescent cells and impair their anti-tumor activity
Senescent cells secrete many molecules, which contribute to the prevention of cancer progression. We induced MSC senescence by oxidative stress, DNA damage, and replicative exhaustion. The first two are considered inducers of acute senescence while extensive proliferation triggers replicative senesc...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003018 | Pride
Mesenchymal stem cells  senescence  secretome  apoptosis  cancer 
UnknownEffect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes.
Not available
S-EPMC10734790 | biostudies-literature
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