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ProteomicsIntegrated multi-omics reveals common properties underlying stress granule and P-body formation
Non-membrane-bound compartments such as mRNA processing bodies (PBs) and stress granules (SGs) play important roles in the regulation of gene expression following environmental stresses. We have systematically determined the protein and mRNA composition of PBs and SGs formed in response to a common ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-11-03 | PXD018762 | Pride
Stress granule purification P-body purification Saccharomyces cerevisiae 
TranscriptomicsThe Extracellular RNA Quality Control (exRNAQC) study: Small RNA sequencing of RNA purification kit study (exRNAQC011)
To evaluate the impact of the RNA purification method on extracellular RNA (exRNA) sequencing, 8 different RNA purification kits were compared by applying Small RNA sequencing (Illumina) to exRNA from human healthy donor plasma. Minimum and maximum plasma input volumes recommended by the manufacture...
ORGANISM(S): Homo sapiens 
2021-06-10 | E-MTAB-10505 | biostudies-arrayexpress
TranscriptomicsTissue-specific nuclei purification from animal models for genome-wide expression and chromatin profiling.
Here we describe a method for purifying nuclei from specific tissues of animal models that allows simultaneous analysis of both expression and chromatin profiles. The method is based on in vivo labeling of the nuclear envelope and subsequent affinity purification. We describe the use of the method t...
ORGANISM(S): Caenorhabditis elegans 
2011-12-05 | E-GEOD-31602 | biostudies-arrayexpress
TranscriptomicsImmunomagnetic purification of mES derived neuronal precursors increases neuronal migration and differentiation in vivo
All established protocols for differentiation of mouse and human pluripotent stem cells into specific neural subpopulations generate a considerable cellular heterogeneity that hampers experimental and clinical progress. In order to obtain a homogenous population of neuronal precursor cells and to st...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-35125 | biostudies-arrayexpress
UnknownP-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes.
Not available
S-EPMC4501357 | biostudies-literature
TranscriptomicsThe Extracellular RNA Quality Control (exRNAQC) study: RNA Exome sequencing of RNA purification kit study (exRNAQC004)
To evaluate the impact of the RNA purification method on extracellular RNA (exRNA) sequencing, 8 different RNA purification kits were compared by applying RNA Exome sequencing (Illumina) to exRNA from human healthy donor plasma. Minimum and maximum plasma input volumes recommended by the manufacture...
ORGANISM(S): Homo sapiens 
2021-05-10 | E-MTAB-10504 | biostudies-arrayexpress
ProteomicsP falciparum Pf377 protein complex in gametocytes
The identification of Pf377 interacting proteins in the osmiophilic bodies in P. falciparum gametocytes. In a comparative proteomics approach, immunopurified Pfg377 complexes were obtained in wild type and Osmiophilic Body -depleted gametocytes (Pf377 knock out gametocytes) and were analyzed by LC-M...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2018-10-26 | PXD004088 | Pride
Gametocyte Malaria Pf377 Osmiophilic body P. falciparum 
ProteomicsP bodies coat germ granules to promote transgenerational gene silencing in C. elegans
Formation of biomolecular condensates have emerged as a critical mechanism for compartmentation in living cells. Despite interactions between distinct condensates have been reported, the biological relevance of such interactions remains elusive. In germ cells, small RNA silencing factors are enriche...
ORGANISM(S): Caenorhabditis elegans 
2023-06-16 | PXD037342 | Pride
Cgh-1 P body Germ granule Rnai inheritance 
TranscriptomicsADAM-28: A potential oncogene involved in asbestos-related lung adenocarcinomas
To identify gene expression biomarkers associated with asbestos-related lung adenocarcinoma, we analyzed primary tumour gene expression for a total of 36 primary lung adenocarcinomas on 22,323 element microarrays, comparing 12 patients with lung asbestos body counts above levels associated with urba...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20875 | biostudies-arrayexpress
MetabolomicsPROMIS, global analysis of PROtein-Metabolite Interactions using Size separation in Arabidopsis thaliana
Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
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