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TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
ProteomicsStructure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Rho GTPases regulate actin dynamics and cell motility, and their hyperactivation drives cancer metastasis1. P-Rex (PI(3,4,5)P3-dependent Rac Exchanger) guanine nucleotide exchange factors (GEFs) are potent on-switches for Rho GTPase signalling and are frequently dysregulated in metastatic cancer2. P...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034327 | Pride
Cancer Rac1 Cryo-em P-rex1 Metastasis 
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | GSE77974 | GEO
ProteomicsThe pseudokinase NRBP1 activates Rac/Cdc42 via P-Rex1 to drive oncogenic signalling in triple negative breast cancer
In an effort to identify oncogenic protein kinase drivers in triple negative breast cancer (TNBC), we undertook mass spectrometry (MS)-based proteomic profiling across a large panel of TNBC cell lines. This revealed marked variation in expression of the multidomain pseudokinase Nuclear Receptor Bind...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD032168 | Pride
G proteins Proteomics Signal transduction Scaffold proteins 
UnknownMultisite phosphorylation of P-Rex1 by protein kinase C.
Not available
S-EPMC5363633 | biostudies-literature
UnknownProtein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.
Not available
S-EPMC4813559 | biostudies-literature
UnknownP-Rex1 is required for efficient melanoblast migration and melanoma metastasis.
Not available
S-EPMC3400057 | biostudies-literature
UnknownCharacterization of a P-Rex1 gene signature in breast cancer cells.
Not available
S-EPMC5239479 | biostudies-literature
UnknownP-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.
Not available
S-EPMC6033363 | biostudies-literature
UnknownP-Rex1 Cooperates With TGFβR2 to Drive Lung Fibroblast Migration in Pulmonary Fibrosis.
Not available
S-EPMC8326510 | biostudies-literature
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