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UnknownA multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease.
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S-EPMC11915002 | biostudies-literature
ProteomicsMultiomics approaches in Alexander disease zebrafish model show correlation between GFAP aggregation, altered lipid metabolism and oxidative stress
In this work we used our zebrafish model of Alexander Desease (AxD), aiming at unraveling the main pathways involved in AxD pathogenesis performing the first multi-omics analysis on a in vivo model of AxD. The obtained results have been functionally validated and they open the way to further investi...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-03-03 | PXD040214 | Pride
P.r239c mutation Danio rerio Alexander disease Gfap Zebrafish 
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