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TranscriptomicsRNAi profiling of mouse chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity, experiment A
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11240 | biostudies-arrayexpress
GenomicsHdac6 regulates Tip60-p400 function in stem cells (sequencing)
The Tip60 (also known as Kat5) lysine acetyltransferase functions broadly as a transcriptional co-activator that acetylates histones. In contrast, Tip60 functions in embryonic stem cells (ESCs) both to silence genes that promote differentiation and to activate genes required for proliferation. The m...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-42209 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
This SuperSeries is composed of the following subset Series: GSE11240: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment A GSE11241: An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Id...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11243 | biostudies-arrayexpress
TranscriptomicsAn RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity, Experiment B
Proper regulation of chromatin structure is necessary for the maintenance of cell type-specific gene expression patterns. The embryonic stem cell (ESC) expression pattern governs self-renewal and pluripotency. Here, we present an RNAi screen in mouse ESCs of 1008 loci encoding chromatin proteins. We...
ORGANISM(S): Mus musculus 
2008-07-11 | E-GEOD-11241 | biostudies-arrayexpress
TranscriptomicsChip-chip from HCT116 cells with p400 antibody
The chromatin remodeller p400 has oncogenic properties that promote early steps of colon cancer. Chromatin immunoprecipitation (ChIP) of p400 together with chromatin profiling by ChIP-on-chip analysis demonstrated that p400 directly binds the chromatin at promoters of p400 target genes. Study of p40...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-45614 | biostudies-arrayexpress
MetabolomicsAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...
2019-05-24 | MTBLS836 | MetaboLights
TranscriptomicsExpression analysis of HCT116 cells transfected using Tip60 or p400-targetting siRNA
Investigation of whole genome gene expression level changes in HCT116 cells upon knockdown of Tip60 or p400, compared to control siRNA-transfected cells. Two different siRNA directed against Tip60 were used and experiments were done in duplicate. Same for p400-targetting or control siRNA. Hybridizat...
ORGANISM(S): Homo sapiens 
2013-11-22 | E-GEOD-45615 | biostudies-arrayexpress
GenomicsChip-chip from HCT116 cells with p400 antibody
The chromatin remodeller p400 has oncogenic properties that promote early steps of colon cancer. Chromatin immunoprecipitation (ChIP) of p400 together with chromatin profiling by ChIP-on-chip analysis demonstrated that p400 directly binds the chromatin at promoters of p400 target genes.
ORGANISM(S): Homo sapiens 
2013-11-22 | GSE45614 | GEO
UnknownHdac6 regulates Tip60-p400 function in stem cells.
Not available
S-EPMC3843111 | biostudies-literature
UnknownControl of alternative end joining by the chromatin remodeler p400 ATPase.
Not available
S-EPMC4770216 | biostudies-literature
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