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TranscriptomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (Exon)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-23 | E-GEOD-22184 | biostudies-arrayexpress
TranscriptomicsHow post-translational modification of nitrogenase is circumvented in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively
Characterization of post-translational modification of nitrogenase in Rhodopseudomonas palustris strains that produce hydrogen gas constitutively. To characterize the effect of yeast extract as nitrogen source on gene expression under nitrogen fixing conditions, expression profiles of wild-type cell...
ORGANISM(S): Rhodopseudomonas palustris 
2012-03-15 | E-GEOD-32292 | biostudies-arrayexpress
GenomicsPhosphorylation of p53 Serine 46 contributes to target gene selectivity of p53 (ChIP-seq)
The tumor suppressor p53 plays a crucial role in cellular growth control inducing a plethora of cellular response pathways. The molecular mechanisms that discriminate between the distinct p53-responses towards different stress treatments have remained largely elusive. Here, we have analyzed the p53-...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21939 | biostudies-arrayexpress
ProteomicsLC-MS data of peptides from p53 isolated by custom immunoaffinity chromatography
We exploited a primary human fibroblast system in which the p53 tumor suppressor protein accumulates to high concentrations due to infection by an adenovirus type 5 mutant that lacks the E1B 55kDa E3 ubiquitin ligase, which targets p53 for degradation, to examine select post-translational modificati...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2013-10-17 | PXD000464 | Pride
P53 post-translational modification 
ProteomicsIdentification of cGAS post-translational modifications
DNA derived from the genetic material of pathogens or from cellular DNA damage provides a molecular pattern that can be sensed by pattern-recognition receptors of the mammalian innate immune system. In recent years, the cyclic GMP-AMP synthase (cGAS) protein has been characterized as a primary cytos...
ORGANISM(S): Homo Sapiens 
2020-05-08 | PXD017133 | panorama
UnknownExtensive post-translational modification of active and inactivated forms of endogenous p53.
Not available
S-EPMC3879606 | biostudies-literature
Proteomicsp53 forms redox-dependent protein-protein interactions through cysteine 277
Reversible cysteine oxidation plays an essential role in redox signaling by reversibly altering protein structure and function. Cysteine oxidation may lead to intra- and intermolecular disulfide formation, and the latter can drastically stabilize protein-protein interactions in a more oxidizing mili...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026893 | Pride
P53 redox-dependent protein-protein interactions cysteine 
TranscriptomicsTP53 sequence of human glioblastoma stem cells sorted for p53-Ser15 induction and NS1 virus protein expression upon parvovirus MVMp infection
We have analyzed whether mutations in the TP53 gene and post-translational phosphorylation in the Ser-15 residue of the p53 protein (Pp53) may confer permissiveness to the prototype strain of the parvovirus Minute Virus of MIce ( MVMp) infection in human glioblastoma stem cells (GSCs) isolated from ...
ORGANISM(S): Homo sapiens 
2021-07-13 | E-MTAB-9359 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human H1299 cellls transformed with different p73/p53 constructs shows C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
The p53 family is known as a family of transcription factors with functions in tumor suppression and development. Whereas the central DNA binding domain is highly conserved among the three family members p53, p63 and p73, the C-terminal domains (CTDs) are diverse and subject to alternative splicing ...
ORGANISM(S): Mus musculus 
2008-10-18 | E-GEOD-8660 | biostudies-arrayexpress
UnknownRegulating tumor suppressor genes: post-translational modifications.
Not available
S-EPMC7293209 | biostudies-literature
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