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GenomicsPABP stabilizes select mRNAs populations in human cells
PABP stabilizes select mRNAs populations in human cells
PRJNA777575 | ENA
GenomicsAlteration of gene expression in ubr-5(-) and pabp-2(RNAi)
Alteration of gene expression in ubr-5(-) and pabp-2(RNAi)
PRJNA1089166 | ENA
TranscriptomicsCoordinated posttranscriptional mRNA population dynamics during T-cell activation
Although RNA-binding proteins (RBPs) coordinate many key decisions during cell growth and differentiation, the dynamics of RNA–RBP interactions have not been extensively studied on a global basis. We immunoprecipitated endogenous ribonucleoprotein complexes containing HuR and PABP throughout a T-cel...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-11989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila photoreceptor cells by
The method of mRNA tagging was recently developed to isolate mRNA population from muscle tissues in Caenohabditis elegans. This method utilizes a FLAG-tagged poly(A)-binding protein (PABP), which can bind to poly(A)-tail of eukaryotic mRNA. Thus, the mRNA population from specific tissue, in which FL...
ORGANISM(S): Drosophila melanogaster 
2008-06-12 | E-GEOD-1790 | biostudies-arrayexpress
TranscriptomicsPABP stabilizes select mRNAs populations in human cells
Gene expression is tightly regulated at the levels of both mRNA translation and stability. The poly(A) binding protein (PABP) plays a role in regulating these processes by binding the mRNA 3´ poly(A) tail and interfacing with both the translation initiation and mRNA deadenylation machineries. Here w...
ORGANISM(S): Homo sapiens 
2021-12-31 | GSE187450 | GEO
TranscriptomicsGenomic analyses reveal miR-137 broad impact on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells
miR-137 plays critical roles in the nervous system and tumor development. An increase in its expression is required for neuronal differentiation while its reduction is implicated in gliomagenesis. To evaluate the potential of miR-137 in glioblastoma therapy, we conducted genome-wide target mapping i...
ORGANISM(S): Homo sapiens 
2014-02-11 | E-GEOD-53220 | biostudies-arrayexpress
TranscriptomicsComprehensive assembly and spatio-temporal analysis of the C. elegans 3' UTRome through isolation and sequencing of 3'UTRs in germline-dereived cell types and somatic tissues.
Our computational analyses of sequencing depth and the discovery rates of sequence elements in the 3M-bM-^@M-^YUTR strongly demonstrate that interrogation of the 3M-bM-^@M-^YUTRome in specific tissues and cell types across development will greatly expand the identification of new 3M-bM-^@M-^YUTR iso...
ORGANISM(S): Caenorhabditis elegans 
2011-11-04 | E-GEOD-33431 | biostudies-arrayexpress
GenomicsTransgenesis of mammalian PABP reveals new role of mRNA polyadenylation in general stress response in Escherichia coli
Transgenesis of mammalian PABP reveals new role of mRNA polyadenylation in general stress response in Escherichia coli
PRJNA702501 | ENA
TranscriptomicsAlteration of gene expression in ubr-5(-) and pabp-2(RNAi)
To investigate how UBR-5 and PABP-2 affect gene expression profile, we generated ubr-5(-) c elegans mutant and performed RNA seq in combination with pabp-2(RNAi).
ORGANISM(S): Caenorhabditis elegans 
2024-09-30 | GSE261826 | GEO
GenomicsNicotiana benthamiana
Nb. PABP-RIP-seq (PRJCA047819)
PRJDB39521 | ENA
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