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TranscriptomicsModulation of calcium activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker- like cells
Background: Ion channels are key determinants for the function of excitable cells but little is known about their role and involvement during cardiac development. Earlier work identified Ca2+-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-18660 | biostudies-arrayexpress
TranscriptomicsGenome-wide mRNA expression analyses revealed dysregulation of genes important for SAN function in Hcn4-CreERT2;Isl1 mutants.
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-24 | E-GEOD-69097 | biostudies-arrayexpress
GenomicsGenome-wide chromatin-immunoprecipitation studies of purified SAN cells reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in SAN cells
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-68974 | biostudies-arrayexpress
TranscriptomicsMouse sinoatrial node transcriptome
RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells Rationale: Treatment of sinus node disease with regenerative or cell-based therapies will require a detailed understanding of gene regulatory networks in cardiac pacemaker cells (PCs)....
ORGANISM(S): Mus musculus 
2015-02-06 | E-GEOD-65658 | biostudies-arrayexpress
TranscriptomicsWhole-genome expression data from purified larval Drosophila LNv pacemaker neurons
We generated whole genome expression profiles from a homogeneous population of purified pacemaker neurons (ventral Lateral Neurons, LNvs) from wild type and clock mutant Drosophila. The study identifes a group of genes whose expression is highly enriched in LNvs compared to other neurons; and a seco...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-35752 | biostudies-arrayexpress
GenomicsA single cell transcriptional roadmap of human pacemaker cell differentiation
A single cell transcriptional roadmap of human pacemaker cell differentiation
PRJNA784514 | ENA
GenomicsRegulatory landscape of human stem cell-derived sinoatrial node-like pacemaker cells and ventricle-like cells
Regulatory landscape of human stem cell-derived sinoatrial node-like pacemaker cells and ventricle-like cells
PRJNA609115 | ENA
GenomicsAdeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2
Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2
PRJNA1312073 | ENA
GenomicsSingle-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [hPSC_SAN]
Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [hPSC_SAN]
PRJNA1173738 | ENA
GenomicsSingle-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [fetal SAN]
Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes [fetal SAN]
PRJNA1173739 | ENA
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