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TranscriptomicsBreast cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50811 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of rat dorsal root ganglions treated with paclitaxel against untreated controls
L4-L5 segment dorsal root ganglion (DRG) samples from controls and the paclitaxel-induced peripheral neuropathy (PIPN) rats were collected at day 14 after the initiation of paclitaxel treatment. Paclitaxel and vehicle were administered intraperitoneally at 2 mg/kg for four consecutive days at a fina...
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13430 | biostudies-arrayexpress
TranscriptomicsPaclitaxel resistant MDA-MB-231 Cells and resensitization with bexarotene treatment
Acquired drug resistance represents a major challenge in chemo-therapy treatment for various types of cancers. We have found that the retinoid X receptor–selective agonist bexarotene (LGD1069, Targretin) was efficacious in treating chemo-resistant cancer cells. The goal of this microarray study w...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-12791 | biostudies-arrayexpress
Transcriptomics16S rRNA gene sequence analysis of feces samples from rats treated with paclitaxel or vehicle controls
To address the role of gut microbiota in the development of paclitaxel-induced peripheral neuropathy (PIPN), we performed 16S rRNA sequencing analysis of feces samples at 14 days and 28 days after the initiation of paclitaxel or vehicle injections.
ORGANISM(S): Rattus norvegicus 
2023-10-16 | E-MTAB-13426 | biostudies-arrayexpress
MetabolomicsQuantitative multi-Omics analysis of paclitaxel-loaded Poly(lactide-co-glycolide) nanoparticles for identification of potential biomarkers for head and neck cancer
Not available
ORGANISM(S): Homo sapiens 
ST002248 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human HMLER breast cancer cells treated with paclitaxel and salinomycin-treated HMLER breast cancer cells
Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. W...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-17215 | biostudies-arrayexpress
TranscriptomicsGene expression data of sensitive, Docetaxel resistant and Paclitaxel resistant MDA-MB-231 Cells
The taxanes, namely Paclitaxel and Docetaxel, are important and widely used cancer chemotherapy drugs in the treatment of invasive and metastatic human breast cancer. Although treatment with the taxanes is beneficial to many patients, drug-responsive tumors in patients with metastatic breast cancer...
ORGANISM(S): Homo sapiens 
2011-04-22 | E-GEOD-28784 | biostudies-arrayexpress
TranscriptomicsPaclitaxel resistance in ovarian cancer increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control
The microtubule-stabilising drug paclitaxel has activity in relapsed ovarian cancer. However, resistance frequently develops. Oncolytic adenoviruses are a novel cancer therapy, and replicate selectively within and lyse malignant cells, leading to productive infection of neighbouring cells. We fou...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-54772 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immature dendritic cells treated with Lipopolysaccharide (LPS) vs Taxol (paclitaxel)
Generation of monocyte-derived dendritic cells (DC). Immature DC were prepared from peripheral blood mononuclear cells (PBMCs) isolated from whole blood of healthy donors. A minimum of 3 individual donor blood was used for each experiment. PBMCs were incubated with anti-CD14 microbeads (Miltenyi Bio...
ORGANISM(S): Homo sapiens 
2009-11-27 | E-MEXP-2465 | biostudies-arrayexpress
TranscriptomicsEndometrial cancer cell lines treated with eribulin and paclitaxel
Eribulin mesylate is a synthetic macrocyclic ketone analog of the marine sponge natural product halichondrin B. Eribulin is a mechanistically unique inhibitor of microtubule dynamics, leading to inhibition of microtubule growth in the absence of effects on microtubule shortening at microtubule plus ...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-50830 | biostudies-arrayexpress
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