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ProteomicsViral biomarker detection and validation using MALDI Mass Spectrometry Imaging (MSI)
INTRODUCTION: Mass Spectrometry Imaging (MSI) is a hybrid mass spectrometry technique that integrates aspects of traditional microscopy and mass spectrometry-based omics analysis. The traditional MALDI TOF/TOF instrument still remains the dominant platform for this type of anal-ysis. However, with r...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD034851 | Pride
Peptide identification Mass spectrometry imaging Maldi 
ProteomicsLyophilization prior to homogenisation and extraction increases membrane protein detection in Gram-negative bacterial proteomic analyses
Multi-drug resistant Gram-negative bacteria (GNB) are major contributors to the anti-microbial resistance (AMR) burden in humans and animals. AMR mechanisms are primarily mediated by proteoforms and, therefore, proteomic analyses of GNB offers a significant advantage in understanding the mechanisms ...
ORGANISM(S): Escherichia coli 
2026-03-08 | PXD075198 | Pride
Proteomics Antimicrobial resistance Membrane proteins Bacterial protein extraction 
ProteomicsSystemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024012 | Pride
Biomarkers Heart failure with preserved ejection fraction Plasma Hypertrophic cardiomyopathy Lc-ms/ms 
ProteomicsMaternal plasma proteome profiling of biomarkers for stratification of early-onset and late-onset preeclampsia
Hypertension in pregnancy is the leading cause of morbidity and mortality in pregnancy, affecting up to 10% of all gestations1. Hypertensive disorders of pregnancy include chronic hypertension, gestational hypertension, eclampsia and pre-eclampsia, all of which increase the risk of complications in ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026931 | Pride
Plasma Preeclampsia Biomarkers Lc-ms/ms 
ProteomicsMatrix directs trophoblast differentiation in a bioprinted organoid model of early placental development
Trophoblast organoids offer a unique opportunity to study mechanisms orchestrating placental growth and development during pregnancy. However, many organoid cultures rely on extracellular matrix reagents that are highly variable and unable to be tuned to reflect in vivo tissues. Here we describe the...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD056796 | Pride
Matrigel Shotgun Organoid Bioprinting Placenta 
ProteomicsAn atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis
The occurrence of a spontaneous nephropathy in laboratory mice, characterized by tubular degeneration and intranuclear inclusions, has puzzled pathologists for over four decades. While the condition takes a more severe course in immunodeficient animals suggesting an infectious cause, its etiology ha...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-06 | PXD010540 | Pride
Miouse Virus Proteomics Liver 
ProteomicsPrimary human airway epithelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2018-01-05 | MSV000081890 | MassIVE
ProteomicsPrimary human microvascular endothelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; Treated with wild-type MERS-CoV, MERS-CoV mutants and mockulum; 5 biological replicates; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2016-08-04 | MSV000080017 | MassIVE
ProteomicsPrimary human airway epithelial cells metabolome response to an icMERS coronavirus
Metabolomics data from cell culture; time points 0, 12, 24, 36 & 48 h
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2018-01-05 | MSV000081889 | MassIVE
ProteomicsHuman Calu-3 cell lipidome response to a wild type infectious clone of H7N9 and mutant H7N9 viruses
Lipidomics data from Calu-3 cell culture; Treated with wild-type and mutant H7N9 and mockulum; Time points 0, 3, 7, 12, 18 & 24 h; 5 biological replicates
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-11-23 | MSV000079386 | MassIVE
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