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ProteomicsFACT, PAF-C, and CKII
Protein-protein interaction analysis for RNA Polymerase II and its elongation factors including: the PAF Complex, the FACT Complex, casein kinase II, DSIF, and TFIIF. These studies also characterized a number of casein kinase II phosphorylation sites on the subunits of the PAF Complex.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-07-20 | MSV000079197 | MassIVE
TranscriptomicsTranscriptomic profiling of human neutrophils after single and sequential stimulation with PAF and fMLP
Human neutrophils isolated from peripheral blood of five healthy male donors were analyzed by one-color microarray to investigate transcriptional changes induced by single and sequential stimulation with platelet-activating factor (PAF) and N-formyl-methionyl-leucyl-phenylalanine (fMLP). The experim...
ORGANISM(S): Homo sapiens 
2026-04-19 | E-MTAB-16930 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling of human neutrophils after single and sequential stimulation with PAF and fMLP
This study evaluated the miRNA expression profile of human neutrophils under resting conditions and after stimulation with PAF and fMLP, applied alone or sequentially. The objective was to determine whether distinct inflammatory stimuli and their order of exposure induce different miRNA expression p...
ORGANISM(S): Homo sapiens 
2026-05-10 | E-MTAB-16957 | biostudies-arrayexpress
TranscriptomicsInfluence of alkyl-phospholipids on the gene expression profile of immortalized keratinocytes HaCaT
New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-20722 | biostudies-arrayexpress
TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
TranscriptomicsImpact of Ino-C2-PAF on the gene expression profile of HaCaT cells after stimulation with pro-inflammatory cytokines
New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-37361 | biostudies-arrayexpress
GenomicsThe PAF complex regulates alternative splicing.
The PAF complex regulates alternative splicing.
PRJNA1052729 | ENA
GenomicsmRNA profiles in PAF KO intestinal adenoma
mRNA profiles in PAF KO intestinal adenoma
PRJNA430110 | ENA
TranscriptomicsThe PAF complex regulates alternative splicing.
The conserved Eukaryotic PAF complex binds to transcribing RNA polymerase II to control deposition of histone marks during transcription. Recently its role in alternative polyadenylation (selection of mRNA 3’end cleavage sites by CPSF) was described. In this work we show that the PAF complex also re...
ORGANISM(S): Homo sapiens 
2024-11-05 | GSE250246 | GEO
Genomicsgene expression of KYSE510 cells with treatment of 100 nM PAF for 24 hours
gene expression of KYSE510 cells with treatment of 100 nM PAF for 24 hours
PRJNA685800 | ENA
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