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TranscriptomicsQuantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution
Phenotypic differences between closely related species are thought to arise primarily from changes in gene expression due to mutations in cis-regulatory sequences (enhancers). However, it has remained unclear, how frequently mutations alter enhancer activity or create functional enhancers de novo. H...
ORGANISM(S): Drosophila willistoni 
2014-04-28 | E-GEOD-48251 | biostudies-arrayexpress
TranscriptomicsEnhancer-core promoter specificity separates developmental and housekeeping regulation
Gene transcription in animals involves the assembly of the RNA polymerase II complex at core promoters and its cell type-specific activation by genomic enhancers that can be located more distally. However, how ubiquitous expression of housekeeping genes is achieved has remained less clear. In partic...
ORGANISM(S): Drosophila melanogaster 
2014-12-10 | E-GEOD-57876 | biostudies-arrayexpress
GenomicsGenome-wide Ultrabithorax binding analysis reveals highly targeted genomic loci at developmental regulators and a potential connection to Polycomb-mediated regulation
Hox homeodomain transcription factors are key regulators of animal development. They specify the identity of segments along the anterior-posterior body axis in metazoans by controlling the expression of diverse downstream targets, including transcription factors and signaling pathway components. The...
ORGANISM(S): Drosophila melanogaster 
2016-07-03 | E-GEOD-64284 | biostudies-arrayexpress
TranscriptomicsThe epigenetic landscape of human colorectal cancer
We characterized the epigenetic landscape of human colorectal cancer (CRC). To this extent, we performed gene expression profiling using high throughput sequencing (RNA-seq) and genome wide binding/occupancy profiling (ChIP-seq) for histone modifications correlated to transcriptional activity, enhan...
ORGANISM(S): Homo sapiens 
2021-02-23 | E-MTAB-8416 | biostudies-arrayexpress
TranscriptomicsThe epigenetic landscape of human colorectal cancer
We characterized the epigenetic landscape of human colorectal cancer (CRC). To this extent, we performed gene expression profiling using high throughput sequencing (RNA-seq) and genome wide binding/occupancy profiling (ChIP-seq) for histone modifications correlated to transcriptional activity, enhan...
ORGANISM(S): Homo sapiens 
2021-03-10 | E-MTAB-8448 | biostudies-arrayexpress
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